930660

Pomalidomide 4′-PEG₃-amine hydrochloride

≥95%

• 同義詞: 1H-Isoindole-1,3(2H)-dione hydrochloride, 4-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione hydrochloride, 4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl) hydrochloride
• 經驗公式（希爾表示法）: C₂₁H₂₈N₄O₇ · xHCl
• CAS號碼: 2446474-09-3
• 分子量：: 448.47 (free base basis)
• MDL號碼: MFCD32063491
• 分類程式碼代碼: 12352116
• NACRES: NA.21

屬性

• ligand: pomalidomide
• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder
• 官能基: amine
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCN)=CC=C3)=O)=O

描述

應用

Pomalidomide 4′-PEG₃-amine Hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.


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其他說明

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

法律資訊

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable