930083

2-(Pyrimidin-5-yl)phenol

≥95%

• 同義詞: Maiti-Bag-Dutta Auxiliary
• 經驗公式（希爾表示法）: C₁₀H₈N₂O
• CAS號碼: 18313-50-3
• 分子量：: 172.18
• MDL號碼: MFCD06802618
• 分類程式碼代碼: 12352100
• NACRES: NA.21

屬性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder
• mp: 173 °C
• 儲存溫度: −20°C

描述

應用

2-(Pyrimidin-5-yl)phenol is a temporary directing group (TDG) to assist as a co-catalyst for metal catalyzed C-H functionalization. Often in C-H functionalization, an auxiliary compound is used to control site selectivity. These traditionally are covalently bonded to the compound of interest, and must subsequently be removed after functionalization, like a typical protecting group. To simplify the process of C-H functionalization, 2-Fluoro-6-(pyrimidin-5-yl)aniline is one of a series of temporary directing groups developed by Deb Maiti′s lab that promote site selectivity without the inclusion of additional synthetic steps.

2-(Pyrimidin-5-yl)phenol is an effective TDG for meta directed C-H functionalization of substitutes with a variety of electron withdrawing functional groups, with high selectivity.

其他說明

Arene diversification through distal C(sp2)−H functionalization
Palladium-Catalyzed meta-C–H Allylation of Arenes: A Unique Combination of a Pyrimidine-Based Template and Hexafluoroisopropanol

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable