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Merck
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Key Documents

915343

Sigma-Aldrich

Maleimide-poly(ethylene glycol)-b-poly(ε-caprolactone)

PEG average Mn 5,000, PCL average Mn 10,000

同義詞:

Maleimide PEG-PCL diblock copolymer, PEG-b-PCL, PEG-PCL

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About This Item

線性公式:
C7H7N2O3[C2H4O]n[C6H10O2]mH
分類程式碼代碼:
12352111
NACRES:
NA.23

形狀

powder or solid

品質等級

分子量

PCL average Mn 10,000 (by NMR)
PCL average Mn 10,000
PEG average Mn 5,000 (by NMR)
PEG average Mn 5,000

顏色

off-white to yellow

蛋白質二硫鍵異構酶

≤1.4 (by GPC)

儲存溫度

−20°C

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應用

Maleimide-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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