907308

(3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol

≥95%

• 同義詞: Hydroxyl diazirine difluoro TIPS-alkyne, MI-PAL, Minimally interfering photoaffinity label, Photo-click tag, Probe building block
• 經驗公式（希爾表示法）: C₁₄H₂₄F₂N₂OSi
• CAS號碼: 2227014-08-4
• 分子量：: 302.44
• MDL號碼: MFCD32667402
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥95%
• 形狀: liquid
• 存貨情形: available only in USA
• 儲存溫度: −20°C
• SMILES 字串: [Si](C(C)C)(C(C)C)(C(C)C)C#CC(F)(F)C1(N=N1)CO
• InChI: 1S/C14H24F2N2OSi/c1-10(2)20(11(3)4,12(5)6)8-7-13(15,16)14(9-19)17-18-14/h10-12,19H,9H2,1-6H3
• InChI 密鑰: SKAPASYQQQYNJK-UHFFFAOYSA-N

描述

應用

(3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol is a minimally interfering photo-affinity label (MI-PAL). Photoaffinity labeling is of growing interest in chemical biology and drug discovery research to characterize the non-covalent interactome and is used in protein profiling; the study of protein-protein interactions and complexes; and target engagement, identification, or validation studies. This MI-PAL contains a diazirine for UV light-induced (∼365 nm) covalent modification of a biological target with potential for downstream applications via the click chemistry-enabling alkyne tag. Its small size exhibits minimal perturbation of the interactions between proteins and the ligand or probe. The Woo lab demonstrated the electronic tuning of this MI-PAL with the placement of stability-imparting fluorine groups adjacent to the diazirine and alkyne. The alkyl fluorine ion losses are also a useful marker in collision-induced dissociation (CID) mass spectrometry experiments. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

其他說明

Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small moleculeeprotein interactions

安全資訊

• 象形圖: GHS02
• 訊號詞: Danger
• 危險聲明: H242
• 防範說明: P210 - P234 - P235 - P240 - P370 + P378 - P403
• 危險分類: Self-react. C
• 儲存類別代碼: 5.2 - Organic peroxides and self-reacting hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable