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重要文件

554324

Sigma-Aldrich

二硫化二苯乙酰

96%

同義詞:

二苯乙酰基二硫化物, 双(苯乙酰基)二硫化物

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About This Item

線性公式:
(C6H5CH2COS)2
CAS號碼:
分子量::
302.41
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

96%

形狀

solid

mp

59-63 °C (lit.)

官能基

disulfide
phenyl

SMILES 字串

O=C(Cc1ccccc1)SSC(=O)Cc2ccccc2

InChI

1S/C16H14O2S2/c17-15(11-13-7-3-1-4-8-13)19-20-16(18)12-14-9-5-2-6-10-14/h1-10H,11-12H2

InChI 密鑰

IXGZXXBJSZISOO-UHFFFAOYSA-N

一般說明

苯乙酰二硫化物在磷酸盐制备过程中用作硫化试剂。苯乙硫醇磺酸盐与硫代乙酸在三乙胺的作用下反应可合成苯基乙酰二硫化物。

應用

苯乙酰二硫化物(PADS)可作为硫转移剂用于硫代磷酸寡核苷酸。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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Synthesis of antisense oligonucleotides: Replacement of 3H-1, 2-benzodithiol-3-one 1, 1-dioxide (Beaucage reagent) with phenylacetyl disulfide (PADS) as efficient sulfurization reagent: From bench to bulk manufacture of active pharmaceutical ingredient.
Cheruvallath ZS, et al.
Organic Process Research & Development, 4(3), 199-204 (2000)
A study on the use of phenylacetyl disulfide in the solid-phase synthesis of oligodeoxynucleoside phosphorothioates.
Roelen HCPF, et al.
J. R. Neth. Chem. Soc., 110(7-8), 325-331 (1991)
"Organic disulfides and related substances. XXIII. Unsymmetrical carbonyl disulfides and cognate compounds"
Fiel L and Buckman DJ
The Journal of Organic Chemistry, 32(11), 3467-3470 (1967)
Honglu Zhang et al.
Journal of the American Chemical Society, 128(51), 16464-16465 (2006-12-21)
The activation of phosphatidylinositol 3-kinase (PI 3-K) and subsequent production of PtdIns(3,4,5)P3 launches a signal transduction cascade that impinges on a plethora of downstream effects on cell physiology. Control of PI 3-K and PtdIns(3,4,5)P3 levels is an important therapeutic target
Use of phenylacetyl disulfide (PADS) in the synthesis of oligodeoxyribonucleotide phosphorothioates.
Cheruvallath ZS, et al.
Nucleosides, nucleotides & nucleic acids, 18(3), 485-492 (1999)

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