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About This Item
經驗公式（希爾表示法）:
C9H18ClNO2
CAS號碼:
分子量：:
207.70
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22
推薦產品
化驗
97%
mp
113-117 °C (lit.)
SMILES 字串
Cl[H].OC(=O)CCCC1CCNCC1
InChI
1S/C9H17NO2.ClH/c11-9(12)3-1-2-8-4-6-10-7-5-8;/h8,10H,1-7H2,(H,11,12);1H
InChI 密鑰
UTPNREIRALGKPW-UHFFFAOYSA-N
一般說明
4-Piperidine butyric acid hydrochloride participates in the synthesis of FK866 [(E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide], an inhibitor of NAD biosynthesis.
應用
Reactant for:
Modification of 3-amidinophenylalanine-derived matriptase inhibitors
Reactions between Weinreb amides and 2-magnesiated oxazoles
Reactant for synthesis of:
NAmPRTase inhibitors
FK866 analogs for NAD salvage inhibition
Modification of 3-amidinophenylalanine-derived matriptase inhibitors
Reactions between Weinreb amides and 2-magnesiated oxazoles
Reactant for synthesis of:
NAmPRTase inhibitors
FK866 analogs for NAD salvage inhibition
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
210.2 °F - closed cup
閃點（°C）
99 °C - closed cup
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Characterization of NAD uptake in mammalian cells.
Billington RA, et al.
The Journal of Biological Chemistry, 283(10), 6367-6374 (2008)
Ubaldina Galli et al.
ChemMedChem, 3(5), 771-779 (2008-02-06)
One of the great challenges of medicinal chemistry is to create novel, effective, chemotherapeutic agents that show specificity for cancer cells combined with low systemic toxicity. A novel idea is to target the enzymes of the NAD biosynthesis and recycling
Hyun You et al.
European journal of medicinal chemistry, 46(4), 1153-1164 (2011-02-19)
NAmPRTase (PBEF/Visfatin) plays a pivotal role in the salvage pathway of NAD(+) biosynthesis. NAmPRTase has been an attractive target for anti-cancer agents that induce apoptosis of tumor cells via a declining plasma NAD(+) level. In this report, a series of
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