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一般說明
羟胺是一种弱碱，主要用作有机反应中的还原剂。
應用
作为制备下列化合物的反应物：
- 心血管药物 Nω-羟基-L-精氨酸（NOHA，一氧化氮前体）的前药
- 羟基氨基胍，作为抗癌药
- 非甾体2,3-二氢喹啉糖皮质激素受体激动剂，具有降低的磷酸烯醇丙酮酸羧基激酶（PEPCK）转录激活活性
- 氧氟沙星的羧酰胺衍生物，具有改善的抗菌特性
- 基于香豆素类似物的TNF-α转化酶（TACE）抑制剂
- HIV整合酶抑制剂
訊號詞
Danger
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Carc. 2 - Desen. Expl. 4 - Eye Dam. 1 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 - STOT SE 3
標靶器官
Blood, Respiratory system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
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Analytical and bioanalytical chemistry, 411(21), 5563-5576 (2019-06-19)
The Surface-enhanced Raman spectroscopy (SERS) method based on gold nanoparticles as SERS substrate was investigated for the label-free detection and quantification of probiotic bacteria that are widely used in various pharmaceutical formulations. Indeed, the development of a simple and fast
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Zhou X, et al.
The Journal of Physical Chemistry C, 115(24), 11957-11961 (2011)
Assembly of cyclic peptide dendrimers from unprotected linear building blocks in aqueous solution.
DavidaPallin T.
Chemical Communications (Cambridge, England), 11, 1345-1346 (1996)
A E Cribb et al.
Clinical pharmacology and therapeutics, 51(5), 522-526 (1992-05-01)
The oxidation of sulfamethoxazole to its hydroxylamine metabolite was investigated in vitro with human liver microsomes and in vivo by detection in the urine. Sulfamethoxazole was oxidized to the hydroxylamine in an NADPH-dependent process by liver microsomes prepared from two
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Bioorganic & medicinal chemistry letters, 23(3), 658-662 (2012-12-25)
A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described. Combination of the hydroxy-ethyl-amine anti-malarial phramacophore with the known Mannich base pharmacophore of amodiaquine (57) resulted in promising in vivo active novel
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