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389145

Sigma-Aldrich

（2-羟丙基）-β-环糊精

average Mw ~1,540

同義詞:

(2-Hydroxypropyl)-beta-cyclodextrin

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About This Item

CAS號碼:
128446-35-5
EC號碼:
420-920-1
分類程式碼代碼:
12352201
PubChem物質ID:
24864264
NACRES:
NA.22

形狀

powder

光學活性

[α]23/D +125°, c = 1 in H2O

分子量

average Mw ~1,540

標籤範圍

1.0 molar substitution dextrin

SMILES 字串

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1

InChI 密鑰

ODLHGICHYURWBS-RYJYQAAZSA-N

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一般說明

2-羟丙基-β-环糊精是一种环状低聚糖，可用作药物赋形剂，以提高药物的稳定性和生物利用度。

（2-羟丙基）-β-环糊精是一种羟烷基衍生物，主要用作制剂载体，以增加药物在水中的溶解，从而将药物成功递送至生物系统。通常用作α-、β-和γ-环糊精的替代物。

應用

亲脂性药物的溶解度随着水溶液中的羟丙基-β-环糊精（HBC）浓度线性增加，这是因为HBC与药物形成了复合物。这种客体-宿主型复合物在药物与HBC的非极性空穴间形成，导致溶解度增强。 可以将溶液冻干以产生易溶的粉末。 对家兔和小鼠无毒性。
（2-羟丙基）-β-环糊精可用于：
  • 分别通过薄层色谱（TLC）和高效液相色谱（HPLC）测定药物制剂和纳米颗粒制剂中分析物的分析标准品。
  • 研究主客体与有机低分子量化合物的相互作用，然后使用反相HPLC技术对其进行定量。
  • 作为流动相添加剂，通过HPLC有效分离β-咔啉。
  • 在环糊精修饰的胶束电动色谱（CD修饰的MEKC）中测定盐酸舍曲林及其合成相关产物。
  • 作为手性选择剂，通过毛细管电泳分离泛酸。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number
MKCN9714
MKCM9642
MKCM9540
MKCM2836
MKCJ4657

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存取文件庫

M Agüeros et al.
Journal of pharmaceutical and biomedical analysis, 39(3-4), 495-502 (2005-06-11)
A rapid and simple HPLC method with evaporative scattering detection (ELSD) has been developed for the separation and quantitation of beta-cyclodextrin (beta-CD), 2-hydroxypropyl-beta-cyclodextrin (2-HP-beta-CD) and poly(methyl vinyl ether-co-maleic anhydride) (Gantrez). Separation was carried out on a Zorbax Eclipse XDB-Phenyl narrow
S E Lucangioli et al.
Journal of chromatography. A, 871(1-2), 207-215 (2000-03-29)
In this work development, optimization and validation of a cyclodextrin-modified micellar electrokinetic chromatography (CD-modified MEKC) method is proposed to resolve separation of the sertraline hydrochloride and synthesis-related substances. Sertraline hydrochloride, the cis-(1S,4S) enantiomer form, is used as an antidepressant therapeutic
P K Zarzycki et al.
Analytical and bioanalytical chemistry, 391(8), 2793-2801 (2008-06-20)
The main focus of this study was to explore the capability of native alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and their hydroxypropyl derivatives for host-guest interaction with 7,8-dimethoxyflavone, selected steroids (estetrol, estriol, estradiol, estrone, testosterone, cortisone, hydrocortisone, progesterone and 17alpha-hydroxyprogesterone) and polycyclic
Zhong Wang et al.
Mediators of inflammation, 2011, 848309-848309 (2011-03-16)
Our previous study concerning brain trauma has shown that progesterone could regulate toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) signaling pathway in the brain, which also has been proved to play important roles in early brain injury (EBI)
Shuhua Chen et al.
PloS one, 6(8), e24293-e24293 (2011-09-16)
Previously, we demonstrated that allopregnanolone (APα) promoted proliferation of rodent and human neural progenitor cells in vitro. Further, we demonstrated that APα promoted neurogenesis in the hippocampal subgranular zone (SGZ) and reversed learning and memory deficits in the male triple
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