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H125

Sigma-Aldrich

(2-羟丙基)-γ-环糊精

solid

同義詞:

HGC

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About This Item

CAS號碼:
128446-34-4
分類程式碼代碼:
12352201
NACRES:
NA.77

形狀

solid

品質等級

100

濃度

1.000 mg/mL±0.005

技術

cell culture | mammalian: suitable

顏色

white

溶解度

H2O: 450 mg/mL

運輸包裝

ambient

儲存溫度

room temp

InChI

1S/C51H88O38/c1-14(56)8-73-11-21-42-29(64)36(71)50(81-21)85-40-19(6-54)79-48(34(69)27(40)62)89-44-23(13-75-10-16(3)58)82-51(37(72)30(44)65)86-41-20(7-55)78-47(33(68)26(41)61)88-43-22(12-74-9-15(2)57)80-49(35(70)28(43)63)84-39-18(5-53)76-45(31(66)24(39)59)83-38-17(4-52)77-46(87-42)32(67)25(38)60/h14-72H,4-13H2,1-3H3/t14?,15?,16?,17-,18-,19-,20-,21-,22-,23-,24-,25-,26-,27-,28-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-/m0/s1

InChI 密鑰

ODLHGICHYURWBS-RYJYQAAZSA-N

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應用

(2-Hydroxypropyl)-γ-cyclodextrin has been used to study its inhibitory effect on complement products and the inflammation induced by cholesterol crystals (CCs) from plasma samples.

生化／生理作用

(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative. It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol. It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis. In the Niemann pick disease model, HPγCD reduces cholesterol accumulation.

其他說明

Non-toxic solubilizer. γ-Cyclodextrin (8-glucose units) has a slightly larger cavity and can accommodate larger substrates than β-cyclodextrin.

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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Catherine R Barker et al.
International journal of cancer, 118(11), 2685-2693 (2005-12-31)
The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new approaches
Role of cyclodextrins in improving oral drug delivery
Loftsson T, et al.
The American Journal of Drug and Alcohol Abuse, 261-275 (2004)
Ashutosh Singhal et al.
Scientific reports, 10(1), 8663-8663 (2020-05-28)
Niemann-Pick type C (NPC) disease is a fatal neurodegenerative disorder caused by mutations in NPC1 and NPC2 genes that result in an accumulation of cholesterol in lysosomes. The majority of children with NPC die in adolescence. Currently, no FDA-approved therapies
Daria Cosaceanu et al.
Cancer letters, 222(2), 173-181 (2005-05-03)
Targeted disruption of the insulin-like growth factor 1 receptor (IGF-1R) restricts proliferation of tumor cells and enhances their in vitro radiosensitivity. However, there is little information regarding the effect of IGF-1R expression and function on the lung cancer response to
Complexation Thermodynamics of Cyclodextrins.
Mikhail V. Rekharsky et al.
Chemical reviews, 98(5), 1875-1918 (2002-02-19)
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文章

Cyclodextrins

Many metabolically important compounds, such as lipid-soluble vitamins and hormones, have very low solubilities in aqueous solutions. Various techniques have been used to solubilize these compounds in tissue culture, cell culture, or other water-based applications.

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