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Merck
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重要文件

240931

Sigma-Aldrich

糖精

≥99%

同義詞:

2,3-二羟基-1,2-苯并异噻唑基-3-酮-1,1-二氧化物, 2-磺基苯甲酸亚胺, 邻磺酰苯酰亚胺

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About This Item

經驗公式(希爾表示法):
C7H5NO3S
CAS號碼:
分子量::
183.18
Beilstein:
6888
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

≥99%

形狀

powder

mp

226-229 °C (lit.)

溶解度

acetone: 1g in 12mL(lit.)
alcohol: 1g in 31mL(lit.)
boiling water: 1g in 25mL(lit.)
water: 1g in 25mL(lit.)

SMILES 字串

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI 密鑰

CVHZOJJKTDOEJC-UHFFFAOYSA-N

尋找類似的產品? 前往 產品比較指南

一般說明

人们研究了人工甜味剂——糖精(2-磺基苯甲酰亚胺)的生物降解。人们还研究了它的致癌潜力。

應用


  • 具有增强的理化性质和体内吸收的加巴喷丁-糖精共晶,配制成口崩片:这项研究介绍了加巴喷丁-糖精共晶的制剂,证明了其溶解度和吸收的改善,这有利于药物应用(Soliman等人,2020年,doi:10.1080/10837450.2019.1687521)。

  • 通过与糖精共非晶态制备来提高伊布替尼的溶解度、溶出度和生物利用度:该研究重点是通过与糖精的共非晶态制备来提高伊布替尼的生物利用度,这对于癌症治疗具有重要意义(Shi等人,2019,doi:10.1016/J.xphs.2019.04.031)。

生化/生理作用

哺乳动物的甜促味剂。有人提出,果蝇具有葡萄糖特异性甘油味觉受体结合位点。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

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N H Tran et al.
Bioresource technology, 161, 40-46 (2014-04-01)
The biodegradation of the six artificial sweetening agents including acesulfame (ACE), aspartame (ASP), cyclamate (CYC), neohesperidindihydrochalcone (NHDC), saccharin (SAC), and sucralose (SUC) by nitrifying activated sludge was first examined. Experimental results showed that ASP and NHDC were the most easily
Hellmuth Lilienthal et al.
Toxicology, 311(1-2), 52-60 (2013-02-14)
Many chemicals are known to exhibit endocrine activity and affect reproductive functions in vertebrates and invertebrates. Endocrine effects include influences on sexual differentiation of the brain during development and reproductive and non-reproductive behavior in adult offspring. We previously demonstrated that
Hugh P Morgan et al.
The Biochemical journal, 448(1), 67-72 (2012-08-22)
PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule
Katharine J Tuerke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13709-13717 (2012-10-05)
A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisite for learning disgust reactions to
Rino Ragno et al.
Journal of medicinal chemistry, 50(6), 1241-1253 (2007-02-28)
The screening of the inhibition capabilities of dye-like small molecules from a focused library against both human PRMT1 and Aspergillus nidulans RmtA is reported as well as molecular modeling studies (homology modeling, molecular docking, and 3-D QSAR) of the catalytic

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