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重要文件

133280

Sigma-Aldrich

异腈基正丁烷

97%

同義詞:

1-叔丁基异腈, 1-异氰基丁烷, 丁基异腈, 正丁基异腈

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About This Item

線性公式:
CH3(CH2)3NC
CAS號碼:
分子量::
83.13
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

97%

形狀

liquid

折射率

n20/D 1.396 (lit.)

密度

0.795 g/mL at 25 °C (lit.)

官能基

amine
isonitrile

儲存溫度

2-8°C

SMILES 字串

CCCC[N+]#[C-]

InChI

1S/C5H9N/c1-3-4-5-6-2/h3-5H2,1H3

InChI 密鑰

FSBLVBBRXSCOKU-UHFFFAOYSA-N

應用

用异氰酸丁酯研究了从 生氢一氧化碳嗜热菌中分离得到的一氧化碳脱氢酶-II的晶体结构 。本研究的目的是探讨 NO 激活血蛋白可溶性鸟苷酸环化酶的机制

生化/生理作用

丁基异腈与细胞色素 P450 中血红素的三价铁和二价铁形成络合物

其他說明

可能形成浑浊和/或沉淀,对纯度无影响。

象形圖

FlameExclamation mark

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Flam. Liq. 2

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

69.8 °F - closed cup

閃點(°C)

21 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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分析證明 (COA)

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T H Tahirov et al.
Nature structural biology, 3(5), 459-464 (1996-05-01)
We have determined the structure of n-butylisocyanide-bound Rhodobacter capsulatus cytochrome c'. This is the first example of a ligand-bound structure of a class IIa cytochrome c. Compared with the structure of native cytochrome c', there are significant conformational changes of
D S Lee et al.
Biochemistry, 40(9), 2669-2677 (2001-03-22)
Alkyl-isocyanides are able to bind to both ferric and ferrous iron of the heme in cytochrome P450, and the resulting complexes exhibit characteristic optical absorption spectra. While the ferric complex gives a single Soret band at 430 nm, the ferrous
D Barrick et al.
Biochemistry, 40(13), 3780-3795 (2001-04-13)
The linkage between the proximal histidines and the proximal polypeptide in normal adult human hemoglobin (Hb A) has been proposed to play a major role in transmitting allosteric effects between oxygen binding sites [Perutz, M. F. (1970) Nature 228, 726-734].
C Mouro et al.
European journal of biochemistry, 267(1), 216-221 (1999-12-22)
An 1H-NMR study of ferric cytochrome P450cam in different paramagnetic states was performed. Assignment of three heme methyl resonances of the isocyanide adduct of cytochrome P450 in the ferric low-spin state was recently performed using electron exchange in the presence
Y Imai et al.
Biochimica et biophysica acta, 1337(1), 66-74 (1997-01-04)
Heme-external ligand interactions of P-450nor were examined spectrophotometrically and compared with those of other P-450s. Most nitrogenous ligands induced type II spectral changes on binding to ferric P-450nor, as did other P-450s. In contrast with other P-450s, 2-methylpyridine and 1-butanol

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