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Merck

SCNN1A

sodium channel, non-voltage-gated 1 alpha subunit

同義詞:
BESC2, ENaCa, ENaCalpha, SCNEA, SCNN1
物種:
UniProtKB ID:
基因 ID:
  • Human(6337) Summary: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the alpha subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), a rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2009]
  • Mouse(20276) sodium channel, nonvoltage-gated 1 alpha
  • Rat(25122) sodium channel, nonvoltage-gated 1 alpha
  • cow(282348) sodium channel, non-voltage-gated 1 alpha subunit
  • sheep(443488) sodium channel, non-voltage-gated 1 alpha subunit
  • naked mole-rat(101700410) sodium channel, non-voltage-gated 1 alpha subunit
  • domestic guinea pig(100135613) sodium channel, nonvoltage-gated 1 alpha
  • chicken(396050) sodium channel, non-voltage-gated 1 alpha subunit
  • domestic cat(101091122) sodium channel, non-voltage-gated 1 alpha subunit
  • dog(403650) sodium channel, non-voltage-gated 1 alpha subunit

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Small Molecule - Antagonist

產品編號
描述
物種
利多卡因, powder,
物種
rat, human
拉莫三嗪, ≥98%, powder,
物種
rat, human
利多卡因, analytical standard,
物種
rat, human
5-(N,N-二甲基)阿米洛利 盐酸盐, ,
物種
rat, mouse, human
5-(N,N-环己烷)阿米洛利, ,
物種
rat, human, mouse

Antibodies

產品編號
描述
物種活性
應用
抗-SCNN1A 兔抗, 1 mg/mL, affinity isolated antibody,
物種活性
mouse, rat
應用
immunohistochemistry
western blot
Anti-Epithelial Sodium Channel-α Antibody, Chemicon®, from rabbit,
物種活性
rat
應用
western blot
Anti-α-Epithelial Cell Sodium Channel (20-42) Rabbit pAb, liquid, Calbiochem®,
物種活性
human, rat
應用

Small Molecule - Blocker

產品編號
描述
物種
氨苯蝶啶, ≥99%,
物種
human
氨苯蝶啶, United States Pharmacopeia (USP) Reference Standard,
物種
human
氨苯蝶啶, Pharmaceutical Secondary Standard; Certified Reference Material,
物種
human
氨苯蝶啶, British Pharmacopoeia (BP) Reference Standard,
物種
human
氨苯蝶啶, European Pharmacopoeia (EP) Reference Standard,
物種
human

Small Molecule - Inhibitor

產品編號
描述
物種
苯扎咪 盐酸盐 水合物, ≥98% (HPLC),
物種
mouse, rat, human
Phenamil methanesulfonate salt, solid,
物種
mouse, rat, human
5-(N-甲基-N-异丁基)阿米洛利, ≥98% (TLC), powder,
物種
mouse, rat, human
利多卡因, powder,
物種
rat, human
利多卡因, analytical standard,
物種
rat, human