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Merck

NR1H2

nuclear receptor subfamily 1, group H, member 2

同義詞:
LXR-b, LXRB, NER, NER-I, RIP15, UNR
物種:
Human NR1H2 (7376), Mouse Nr1h2 (22260), Rat Nr1h2 (58851), domestic cat NR1H2 (101087367), cow NR1H2 (509622), Horse NR1H2 (100052399), dog NR1H2 (610057), sheep NR1H2 (101111571), naked mole-rat Nr1h2 (101700273), Domestic Rabbit NR1H2 (100462688)
UniProtKB ID:
P55055, A8K490, Q12970, Q5I0Y1
基因 ID:
  • Human(7376) Summary: The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]
  • Mouse(22260) nuclear receptor subfamily 1, group H, member 2
  • Rat(58851) nuclear receptor subfamily 1, group H, member 2
  • domestic cat(101087367) nuclear receptor subfamily 1, group H, member 2
  • cow(509622) nuclear receptor subfamily 1, group H, member 2
  • Horse(100052399) nuclear receptor subfamily 1, group H, member 2
  • dog(610057) nuclear receptor subfamily 1, group H, member 2
  • sheep(101111571) nuclear receptor subfamily 1, group H, member 2
  • naked mole-rat(101700273) nuclear receptor subfamily 1, group H, member 2
  • Domestic Rabbit(100462688) nuclear receptor subfamily 1, group H, member 2
  • domestic guinea pig(100719951) nuclear receptor subfamily 1, group H, member 2

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Small Molecule - Agonist

產品編號
描述
物種
H3878
猪去氧胆酸, ≥98%,
物種
human
T2320
T0901317, ≥98%,
物種
human

Antibodies

產品編號
描述
物種活性
應用
SAB3500380
Anti-LXR-B antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物種活性
human, mouse, rat
應用
ELISA
western blot
SAB2500606
Anti-LXR α/LXR β antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
物種活性
human
應用
ELISA
western blot

Small Molecule - Mixed Agonist/Antagonist

產品編號
描述
物種
T2320
T0901317, ≥98%,
物種
human

Proteins

產品編號
描述
物種
SRP2057
LXR β-ligand binding domain (211-461) human, recombinant, expressed in E. coli, ≥80% (SDS-PAGE),
物種
human
SRP2138
LXR β isoform, ligand binding domain (211-461), GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
物種
human

esiRNA

產品編號
描述
物種
EHU018341
MISSION® esiRNA, targeting human NR1H2,
物種
human