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Merck

MDM2

MDM2 oncogene, E3 ubiquitin protein ligase

同義詞:
ACTFS, HDMX, hdm2
物種:
Human MDM2 (4193), Mouse Mdm2 (17246), Rat Mdm2 (314856), Zebrafish mdm2 (30637), dog MDM2 (403693), domestic cat MDM2 (493939), cow MDM2 (540378), Horse MDM2 (100033891), chicken MDM2 (395609), domestic guinea pig Mdm2 (100724684) ...更多
UniProtKB ID:
Q00987, A6NL51, A8K2S6, Q13226, Q13297, Q13298, Q13299, Q13300
基因 ID:
  • Human(4193) Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
  • Mouse(17246) transformed mouse 3T3 cell double minute 2
  • Rat(314856) p53 E3 ubiquitin protein ligase
  • Zebrafish(30637) transformed 3T3 cell double minute 2 homolog (mouse)
  • dog(403693) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • domestic cat(493939) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • cow(540378) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • Horse(100033891) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • chicken(395609) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)
  • domestic guinea pig(100724684) MDM2 oncogene, E3 ubiquitin protein ligase
  • naked mole-rat(101724821) MDM2 oncogene, E3 ubiquitin protein ligase
  • sheep(101104979) Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)

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Antibodies

產品編號
描述
物種活性
應用
MABE340
抗-MDM2抗体，克隆IF2, clone IF2, from mouse,
物種活性
human
應用
immunohistochemistry
western blot
OP115
Anti-MDM2 (Ab-2) Mouse mAb (2A10), liquid, clone 2A10, Calbiochem®,
物種活性
human
應用
MABE281
Anti-MDM2 Antibody, clone 2A10, clone 2A10, from mouse,
物種活性
human
應用
immunoprecipitation (IP)
western blot
M8558
单克隆抗-MDM2 小鼠抗, ~2 mg/mL, clone MD-219, purified immunoglobulin, buffered aqueous solution,
物種活性
mouse
應用
ELISA
flow cytometry
immunocytochemistry
microarray
western blot
SAB4503937
Anti-phospho-MDM2 (pSer166) antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
immunofluorescence
immunohistochemistry
western blot

Proteins

產品編號
描述
物種
SRP2095
MDM2, HIS标记 人, recombinant, expressed in E. coli, ≥80% (SDS-PAGE), buffered aqueous solution,
物種
human
M0321
MDM2 人, recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE),
物種
human

esiRNA

產品編號
描述
物種
EHU098571
MISSION® esiRNA, targeting human MDM2,
物種
human