推荐产品
生物源
mouse
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
MD-219, monoclonal
形狀
buffered aqueous solution
分子量
antigen 90 kDa
物種活性
mouse
應無反應活性
human
濃度
~2 mg/mL
技術
flow cytometry: suitable
immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-2 μg/mL using whole extract of transfected 293T (human embryonal kidney) cells, expressing mouse MDM2
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
mouse ... Mdm2(17246)
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一般說明
Mouse 3T3 cell double minute 2 (MDM2) gene was originally found on mouse double minute chromosomes.
Transformed mouse 3T3 cell double minute 2 (MDM2) is an E3 ligase expressed in podocytes. It is overexpressed in lymphomas.
特異性
The antibody shows predominantly nuclear and some cytoplasmic staining in cells.
免疫原
recombinant mouse MDM2.
生化/生理作用
In addition, to regulation MDM2 also mediates the degradation of p53. MDM2 protein has been shown to activate cell proliferation by stimulating the S-phase-inducing transcription factors, E2F1/DP1. Overexpression of MDM2 results in reduced quantities of co-expressed p53, and disruption of the p53-MDM2 interaction by mutation results in both activation and accumulation of p53. The amplification of the MDM2 gene has been demonstrated in various human neoplasms. MDM2 is frequently overexpressed in the nuclei of soft-tissue sarcomas, and to a much lesser extent in a wide variety of malignancies, such as bladder, breast, testes, and cervix cancers, and in glial cells, and a range of hematological disorders. Monoclonal antibody reacting specifically with MDM2 is an essential tool in defining the interactions and distributions of MDM2, its function in signaling pathways and in mutual regulation of p53.
Transformed mouse 3T3 cell double minute 2 (MDM2) acts as a negative regulator of the tumor suppressor p53. It also regulates the cell cycle and inflammatory activities.
外觀
0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
The Journal of pathology, 233(4), 380-391 (2014-05-03)
Mdm2, an E3 ubiquitin ligase, negatively regulates the tumour suppressor p53. In this study we utilized a conditional Mdm2 allele, Mdm2(FM) , and a CAG-CreER tamoxifen-inducible recombination system to examine the effects of global Mdm2 loss in adult mice. Two
Dual Roles of MDM2 in the Regulation of p53: Ubiquitination Dependent and Ubiquitination Independent Mechanisms of MDM2 Repression of p53 Activity
Genes & cancer, 3, 240-240 (2012)
Journal of the American Society of Nephrology : JASN, 26(7), 1513-1523 (2014-10-29)
Murine double minute-2 (MDM2), an E3 ligase that regulates the cell cycle and inflammation, is highly expressed in podocytes. In podocyte injury, MDM2 drives podocyte loss by mitotic catastrophe, but the function of MDM2 in resting podocytes has not been
MDM2 amplification in malignant peripheral nerve sheath tumors correlates with p53 protein expression
Archives of Pathology & Laboratory Medicine, 136, 95-99 (2012)
Oncogene, 27(11), 1590-1598 (2007-09-11)
Mdm2, a regulator of the p53 tumor suppressor, is frequently overexpressed in lymphomas, including lymphomas that have inactivated p53. However, the biological consequences of Mdm2 overexpression in lymphocytes are not fully resolved. Here, we report that increased expression of Mdm2
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