M0321

MDM2 人

recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE)

• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 生物源: human
• 重組細胞: expressed in E. coli
• 描述: contains an N-terminal GST tag
• 化驗: ≥75% (SDS-PAGE)
• 形狀: buffered aqueous glycerol solution
• 分子量: ~84 kDa
• UniProt登錄號: Q00987
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... MDM2(4193)

说明

一般說明

Murine double minute 2 (MDM2) encoding gene is localized at 12q15 in the human chromosome. It is a multidomain nuclear phosphoprotein. It possesses really interesting new gene (RING) finger domain and its function and structural integrity is required for the action of MDM2. It also has central acidic domain.

生化／生理作用

Murine double minute 2 (MDM2) is a chief regulator of the p53 tumor suppressor protein. It is a multifunctional oncoprotein that contributes to both p53-dependent and -independent roles in oncogenesis. MDM2 has various p53-independent functions that contribute to its activity as an oncogene.

Overexpression of Murine double minute 2 (MDM2) is observed in various cancer like lung, gastric, colorectal, hepatocellular, breast, endometrial, and prostate. A common single nucleotide polymorphism is observed at 309 amino acid (from T to G) increases the susceptibility to cancer.

MDM2 is a negative regulator of the p53 tumor suppressor.

Mdm2 functions as an E3 ubiquitin ligase and an inhibitor of p53 transcriptional activation.

外觀

Solution in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF and 25% glycerol.

準備報告

Supplied as a truncated version (202-end) with an N-terminal GST tag

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)