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PHR1100

Supelco

L-Phenylalanine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

(S)-2-Amino-3-phenylpropionic acid

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About This Item

Linear Formula:
C6H5CH2CH(NH2)CO2H
CAS Number:
63-91-2
Molecular Weight:
165.19
Beilstein:
1910408
EC Number:
200-568-1
MDL number:
MFCD00064227
UNSPSC Code:
41116107
PubChem Substance ID:
329823122
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to Ph. Eur. P1150000
traceable to USP 1530503

API family

phenylalanine

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

270-275 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

N[C@@H](Cc1ccccc1)C(O)=O

InChI

1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1

InChI key

COLNVLDHVKWLRT-QMMMGPOBSA-N

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General description

L-Phenylalanine is an essential aromatic amino acid. It has a role in metabolism as it forms a starting point for many pathways. This neutral amino acid is a precursor for tyrosine, epinephrine, dopamine and norepinephrine.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

L-Phenylalanine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7164 in the slot below. This is an example certificate only and may not be the lot that you receive.

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Product No.
Description
Pricing

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
LRAD4403
LRAD1938
LRAB9001
LRAA7164
P500100

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HPLC-fluorescence determination of amino acids in pharmaceuticals after pre-column derivatization with phanquinone
Gatti.R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 35(2), 339-348 (2004)
Ann Mullally et al.
Blood, 121(18), 3692-3702 (2013-03-15)
Interferon-α (IFNα) is an effective treatment of patients with myeloproliferative neoplasms (MPNs). In addition to inducing hematological responses in most MPN patients, IFNα reduces the JAK2V617F allelic burden and can render the JAK2V617F mutant clone undetectable in some patients. The
Vimesh A Avlani et al.
American journal of physiology. Endocrinology and metabolism, 304(10), E1097-E1104 (2013-03-28)
In addition to its acute effects on hormone secretion, epithelial transport, and shape change, the calcium-sensing receptor (CaSR) modulates the expression of genes that control cell survival, proliferation, and differentiation as well as the synthesis of peptide hormones and enzymes.
Stefanie Keil et al.
Pediatrics, 131(6), e1881-e1888 (2013-05-22)
Sapropterin dihydrochloride, the synthetic form of 6R-tetrahydrobiopterin (BH4), is an approved drug for the treatment of patients with BH4-responsive phenylketonuria (PKU). The purpose of this study was to assess genotypes and data on the long-term effects of BH4/sapropterin on metabolic
Minghua Tang et al.
The American journal of clinical nutrition, 99(4), 891-898 (2014-01-17)
Data on the protein requirements of elderly adults are limited, because it is impractical to conduct repeated nitrogen balance protocols in these vulnerable humans. This study was designed to determine the dietary protein requirement of elderly women by using the
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Protocols

GC Analysis of Amino Acids (as TBDMS Derivatives) on SLB®-5ms (20 m x 0.18 mm I.D., 0.18 μm), Fast GC Analysis

Separation of L-Alanine; Glycine; L-Valine; L-Leucine; L-Isoleucine; L-Proline; L-Methionine; L-Serine; L-Threonine; L-Phenylalanine; L-Aspartic acid; L-4-Hydroxyproline; L-Cysteine; L-Glutamic acid; L-Asparagine; L-Lysine; L-Glutamine; L-Histidine; L-Tyrosine; L-Tryptophan; L-Cystine

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