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T2320

Sigma-Aldrich

T0901317

≥98%

Synonym(s):

N-(2,2,2-Trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide

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About This Item

Empirical Formula (Hill Notation):
C17H12NSO3F9
CAS Number:
293754-55-9
Molecular Weight:
481.33
MDL number:
MFCD03412028
UNSPSC Code:
12352106
PubChem Substance ID:
24900032
NACRES:
NA.25

Quality Level

200

Assay

≥98%

mol wt

481.3

storage temp.

−20°C

SMILES string

OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F

InChI

1S/C17H12F9NO3S/c18-14(19,20)10-27(31(29,30)13-4-2-1-3-5-13)12-8-6-11(7-9-12)15(28,16(21,22)23)17(24,25)26/h1-9,28H,10H2

InChI key

SGIWFELWJPNFDH-UHFFFAOYSA-N

Gene Information

human ... ABCA1(19) , NR1H2(7376) , NR1H3(10062)

Application

T0901317 has been used in LXR agonist study in order to observe the expression of all dietary cholesterol-regulated genes in mice. It has also been used to stimulate the radiolabeled peritoneal macrophages from WT (wildtype) and Tg (transgenic) mice for cellular cholesterol efflux assay.

Biochem/physiol Actions

T0901317 can prevent the secretion of insulin by acting on the metabolism of mitochondria.
LXR agonist whose treatment results in an LXR-dependent up-regulation of ABC1 gene expression

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yan Xing et al.
Scientific reports, 6, 21309-21309 (2016-02-19)
Liver X receptors (LXRs) play essential roles in lipogenesis, anti-inflammatory action and hepatic stellate cells (HSCs) activation in the liver. However, the effects of LXRs on the capillarization of liver sinusoidal endothelial cells (LSECs) in liver fibrosis remain undetermined. Here
The LXR ligand T0901317 acutely inhibits insulin secretion by affecting mitochondrial metabolism
Maczewsky J, et al.
Endocrinology, 158(7), 2145-2154 (2017)
Differential Gene Regulation of StarD4 and StarD5 Cholesterol Transfer Proteins ACTIVATION OF StarD4 BY STEROL REGULATORY ELEMENT-BINDING PROTEIN-2 AND StarD5 BY ENDOPLASMIC RETICULUM STRESS
Soccio RE, et al.
The Journal of Biological Chemistry, 280(19), 19410-19418 (2005)
Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice
Maxwell KN, et al.
Journal of Lipid Research, 44(11), 2109-2119 (2003)
Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis
Yamada S, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology, 38(5), 994-1006 (2018)
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The liver excretes excess cholesterol in the form of bile acids. Bile acids serve two purposes: to remove unwanted cholesterol from the body and to aid in lipid digestion in the intestine.

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