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MAK203

Sigma-Aldrich

DPP4 INHIBITOR SCREENING KIT

Sufficient for 100 Fluorometric tests

Synonym(s):

Adenosine Deaminase Complexing Protein-2 Inhibitor Screening Kit, CD26 Inhibitor Screening Kit, Dipeptidyl-Peptidase 4 Inhibitor Screening Kit

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About This Item

UNSPSC Code:
12161503
NACRES:
NA.25

application(s)

pharmaceutical

detection method

fluorometric

relevant disease(s)

endocrinological disorders, diabetes

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... DPP4(1803)
mouse ... DPP4(13482)
rat ... DPP4(25253)

General description

Dipeptidyl-peptidase 4 (DPP4; CD26; adenosine deaminase complexing protein-2) is a membrane glycoprotein with serine exopeptidase activity that cleaves X-proline dipeptides from the N-terminus of polypeptides. Inhibitors of DPP4 inhibit the degradation of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 by DPP4 and have emerged as oral anti-diabetic agents.

Features and Benefits

Compatible with high-throughput handling systems.

Suitability

Suitable for the screening of inhibitors of DPP4.

Principle

The DPP4 Inhibitor Screening Kit is a simple assay suitable for high-throughput screening of potential DPP4 inhibitors. DPP4 activity is measured by cleaving the substrate to yield a fluorescent product (λex = 360/λem = 460 nm), proportional to the enzymatic activity present. The effectiveness of the test inhibitors may be compared with the DPP4 inhibitor (sitagliptin) provided as a control.

Kit Components Only

Product No.
Description
  • DPP4 Assay Buffer
  • DPP4 Substrate
  • DPP4 Enzyme
  • DPP4 Inhibitor, Sitagliptin

Storage Class Code

10 - Combustible liquids

Flash Point(F)

188.6 °F - closed cup

Flash Point(C)

87 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
8M13K07800
7K19K07800
7D16K07800
7B24K07800
6J25K07800

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Paulina Kęska et al.
Nutrients, 14(4) (2022-02-27)
The ability of peptides from an aqueous and salt-soluble protein extract of dry-cured pork loins to inhibit the action of dipeptidyl peptidase IV was determined. This activity was assessed at different times of the production process, i.e., 28, 90, 180

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