T7650
3,3′,5-Triiodothyroacetic acid
≥90%
Synonym(s):
4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenylacetic acid
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All Photos(4)
About This Item
Empirical Formula (Hill Notation):
C14H9I3O4
CAS Number:
Molecular Weight:
621.93
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Recommended Products
Quality Level
Assay
≥90%
form
powder
storage temp.
−20°C
SMILES string
OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
InChI
1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20)
InChI key
UOWZUVNAGUAEQC-UHFFFAOYSA-N
Gene Information
human ... THRA(7067) , THRB(7068)
rat ... Thra(81812) , Thrb(24831)
Application
- Thyroid hormone research: A study explored the impact of 3,3′,5-Triiodothyroacetic acid on peripheral and neurodevelopmental findings in patients with MCT8 deficiency, highlighting its potential in therapeutic interventions for thyroid-related developmental disorders (Unsal and Hayran, 2024).
- Neurological disorder management: Research demonstrated the use of 3,3′,5-Triiodothyroacetic acid in addressing impaired T3 uptake and action in cerebral organoids modeling Allan-Herndon-Dudley syndrome, providing insights into its application in managing brain-specific thyroid hormone transport abnormalities (Salas-Lucia et al., 2024).
- Pharmaceutical development for antiviral therapies: Tiratricol, a derivative of 3,3′,5-Triiodothyroacetic acid, was identified as an inhibitor of yellow fever virus replication by targeting the viral RNA-dependent RNA polymerase, showcasing its potential in antiviral drug development (Ren et al., 2023).
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
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Rie Anzai et al.
Thyroid : official journal of the American Thyroid Association, 22(10), 1069-1075 (2012-09-06)
The effectiveness of short-term 3,5,3'-triiodothyroacetic acid (TRIAC) therapy for the treatment of hyperthyroidism caused by thyroid hormone resistance (RTH) has been documented. Here, we report a 3-year course of TRIAC therapy in an RTH boy, with a quantitative evaluation of
Napoleão F Valadares et al.
Bioorganic & medicinal chemistry, 15(13), 4609-4617 (2007-05-01)
2D QSAR studies were carried out for a series of 55 ligands for the Thyroid receptors, TRalpha and TRbeta. Significant cross-validated correlation coefficients (q(2)=0.781 (TRalpha) and 0.693 (TRbeta)) were obtained. The models' predictive abilities were proved more valuable than the
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Warren J L Wood et al.
Chembiochem : a European journal of chemical biology, 10(2), 361-365 (2008-12-24)
3-Iodothyronamine (T(1)AM) and 3,3',5-triiodothyroacetic acid (Triac) are bioactive metabolites of the hormone thyroxine (T(4)). In the present study, the ability of T(1)AM and 3,3',5-triiodothyronamine (T(3)AM) to be metabolized to 3-iodothyroacetic acid (TA(1)) and Triac, respectively, was investigated. Both T(1)AM and
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