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Merck

1173508

USP

去羟米松

United States Pharmacopeia (USP) Reference Standard

别名:

9-氟-11β,21-二羟基-16α-甲基孕甾-1,4-二烯-3,20-二酮

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About This Item

经验公式(希尔记法):
C22H29FO4
CAS号:
分子量:
376.46
MDL號碼:
分類程式碼代碼:
41116107
NACRES:
NA.24

生物源

synthetic

agency

USP

蒸汽壓力

<0.0000001 kPa ( 25 °C)

API 家族

desoximetasone

形狀

powder

包裝

pkg of 200 mg

製造商/商標名

USP

儲存條件

protect from light

顏色

white

溶解度

acetone: freely soluble
alcohol: freely soluble
benzene: slightly soluble
chloroform: freely soluble
ether: slightly soluble
water: insoluble

應用

pharmaceutical (small molecule)

SMILES 字串

[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C22H29FO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-21(13,3)22(15,23)18(27)10-20(16,2)19(12)17(26)11-24/h6-7,9,12,15-16,18-19,24,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,18+,19-,20+,21+,22+/m1/s1

InChI 密鑰

VWVSBHGCDBMOOT-IIEHVVJPSA-N

基因資訊

human ... NR3C1(2908)

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一般說明

Desoximetasone is a topical corticosteroid known to modify the functions of leukocytes that are mainly responsible for skin infections, inflammation and allergies.

應用

Desoximetasone USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Desoximetasone Cream
  • Desoximetasone Gel
  • Desoximetasone Ointment
  • Dexamethasone

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

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已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

Development and Validation of RP-HPLC Method for Desoximetasone in Bulk and Cream Formulation
Gorle A, et al.
Journal of Drug Delivery and Therapeutics, 9(3), 154-159 (2019)
S Vladimirov et al.
Journal of pharmaceutical and biomedical analysis, 14(8-10), 947-950 (1996-06-01)
The proposed method is based on coloured hydrazone formation with 1,4-dihydrazinophthalazine as a reagent. Heating at 85 degrees C for 2 h was found necessary to ensure optimal hydrazone formation in the presence of hydrochloric acid. The yellow hydrazone product

实验方案

A simple, precise and sensitive Reverse-Phase High Pressure Liquid Chromatography gradient method was adapted for traceability, homogeneity and total chromatographic analysis of Dexamethasone. The given experimental conditions follow the USP43-NF38 monograph method for Dexamethasone Assay and Organic Impurity Profiling. Dexamethasone, Betamethasone, Dexamethasone acetate and Desoximetasone were baseline resolved within 20 minutes using a Titan C18 UHPLC column (2.1 x 100 mm, 1.9 µm).

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