Y0002071

亚叶酸钙

European Pharmacopoeia (EP) Reference Standard

• 别名: 亚叶酸 钙盐 水合物, 5-HCO-H₄PteGlu, 5-甲酰基-5,6,7,8-四氢叶酸 钙盐, 5-甲酰基-5,6,7,8-四氢蝶酰基-L-谷氨酸 钙盐, 叶醛酸钙, 嗜橙菌因子 钙盐, 甲酰四氢叶酸 钙盐
• 经验公式（希尔记法）: C₂₀H₂₁CaN₇O₇ · xH₂O
• CAS号: 1492-18-8
• 分子量: 511.50 (anhydrous basis)
• Beilstein: 5723924
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 生物源: synthetic
• 等級: pharmaceutical primary standard
• agency: EP
• API 家族: folic acid
• 形狀: solid
• 製造商／商標名: EDQM
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: pharmaceutical (small molecule)
• 形式: neat
• 儲存溫度: −20°C
• SMILES 字串: [Ca++].[H]O[H].[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)CNc3nc(N)nc(O)c13
• InChI: 1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12?,13-;/m0./s1
• InChI 密鑰: KVUAALJSMIVURS-ZEDZUCNESA-L

说明

一般說明

Calcium folinate, the reduced form of folic acid, finds application in the treatment of methotrexate overdose and in high-dose methotrexate chemotherapy as a chemotherapy protective drug to bring down the latter′s toxicity. When combined with fluorouracil, it is reported to be effective in the management of bowel cancer wherein it acts by inhibiting thymidylate synthase and augmenting the effect of fluorouracil.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

叶酸拮抗剂通过结合二氢叶酸还原酶并阻滞叶酸转化为四氢叶酸盐发挥作用，而亚叶酸钙则可抵消叶酸拮抗剂的作用。在医学上，亚叶酸钙在甲氨蝶呤治疗后用于降低甲氨蝶呤的毒性。亚叶酸钙还可用于增强癌症治疗中 5-氟尿嘧啶的细胞毒性效应。

Calcium folinate for system suitability may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H315,H317,H319,H334,H335
• 防範說明: P261 - P264 - P280 - P304 + P340 + P312 - P342 + P311
• 危險分類: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable