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15023AST

Supelco

Astec® CHIROBIOTIC® V2 Chiral (5 μm) HPLC Columns

L × I.D. 15 cm × 4.6 mm, HPLC Column

别名:

CHIROBIOTIC V2手性色谱柱

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About This Item

分類程式碼代碼:
41115700
eCl@ss:
32110501
NACRES:
SB.52

产品名称

Astec® CHIROBIOTIC® V2手性HPLC色谱柱, 5 μm particle size, L × I.D. 15 cm × 4.6 mm

材料

stainless steel column

agency

suitable for USP L88

描述

HPLC column

產品線

Astec®

包裝

pkg of 1 ea

製造商/商標名

Astec®

參數

0-45 °C temperature
241 bar pressure (3500 psi)

技術

HPLC: suitable
LC/MS: suitable

長度 × 內徑

15 cm × 4.6 mm

基質

High-purity silica gel particle platform
fully porous particle

基質活性組

vancomycin phase

粒徑

5 μm

孔徑

200 Å

工作pH值範圍

3.5-7.0

分離技術

chiral

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一般說明

中性分子、酰胺、酸、酯和胺对这些基于万古霉素的CSP显示出相当大的对映选择性。在CHIROBIOTIC® V的极性离子模式下,分离出各种各样的仲胺和叔胺分子。CHIROBIOTIC® V已经表现出蛋白质固定相的许多分离特性,但同时具有出色的稳定性和更高的样品容量。一些尚未报道在任何其他手性固定相上得到分离的手性分析物被分离出来。CHIROBIOTIC® V和V2的区别在于键合化学性质与载体颗粒的孔径不同,这赋予它们不同的选择性和制备能力。

  • 键合相:万古霉素
  • 工作pH范围:3.5 - 7.0
  • 粒径:5、10或16 μm
  • 孔径:100Å(CHIROBIOTIC® V)或200Å(CHIROBIOTIC® V2)

CHIROBIOTIC FAQ
CHIROBIOTIC参考书目
Chiral产品文献

應用


  • Development and validation of an UFLC-MS/MS method for enantioselectivity determination of d,l-thero-methylphenidate, d,l-thero-ethylphenidate and d,l-thero-ritalinic acid in rat plasma and its application to pharmacokinetic study.:研究表明Astec® CHIROBIOTIC® V2手性HPLC色谱柱在药动学研究中可用于准确的对映选择性分析,特别是精神活性成分。柱子可有效分离和定量血浆中的手性药物及其代谢物,提供有价值的药物开发和治疗监测信息(Zhang et al., 2016)。

  • New high-performance liquid chromatography method for the determination of (R)-warfarin and (S)-warfarin using chiral separation on a glycopeptide-based stationary phase.:采用Astec® CHIROBIOTIC® V2手性HPLC色谱柱手性分离华法林对映异构体。提供抗凝药物分析的稳健工具,有助药动学评估和用药剂量优化(Malakova et al., 2009)。

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法律資訊

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
Enantioselective and sensitive determination of carvedilol in human plasma using chiral stationary-phase column and reverse-phase liquid chromatography with tandem mass spectrometry
Jiang, Juanjuan, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 960, 92-97 (2014)
Enantioselective determination of doxazosin in human plasma by liquid chromatography?tandem mass spectrometry using ovomucoid chiral stationary phase
Liu, Ke, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 878 (26), 2415-2420 (2010)
Quantitative determination of ondansetron in human plasma by enantioselective liquid chromatography-tandem mass spectrometry
Liu, Ke, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 864 (1-2), 129-136 (2008)
Validation of a chiral liquid chromatography?tandem mass spectrometry method for the determination of pantoprazole in dog plasma
Chen, Meixia, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 906, 85-90 (2012)

商品

Separation of S(+)-Amphetamine (dextro-Amphetamine) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; R(-)-Amphetamine (levo-Amphetamine), 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

Shown here is the chiral separation of amphetamine enantiomers under MS-compatible conditions on Astec CHIROBIOTIC® V2 after extraction from urine using Supel™-Select SCX SPE 96-well plates. The highest grade mobile phase solvents and additives were used to supply low background interference and low particulate contaminants for robust, trouble-free operation. Cerilliant CRMs provided reliable identification and quantification.

实验方案

Optimized sample prep and chiral chromatography methods for the LC/MS analysis of these drug enantiomers in urine

In this study, optimized methods are presented for sample preparation and chiral chromatography for the LC/MS analysis of amphetamine and methamphetamine enantiomers in urine.

LC/MS Analysis of Methamphetamine Enantiomers on Astec® CHIROBIOTIC® V2 in Urine after SPE using Supel™-Select SCX

Chromatograms

application for HPLC

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