推荐产品
product name
Astec® CHIROBIOTIC® TAG 手性 HPLC色谱 柱, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
材料
stainless steel column
品質等級
agency
suitable for USP L63
描述
HPLC column
產品線
Astec®
包裝
pkg of 1 ea
製造商／商標名
Astec®
參數
0-45 °C temperature
241 bar pressure (3500 psi)
技術
HPLC: suitable
LC/MS: suitable
長度 × 內徑
15 cm × 4.6 mm
基質
High-purity silica gel particle platform
fully porous particle
基質活性組
teicoplanin aglycone phase
粒徑
5 μm
孔徑
100 Å
工作pH值範圍
3.0-6.8
分離技術
chiral
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一般說明
去掉三个碳水化合物单体后，CHIROBIOTIC®TAG便有了CHIROBIOTIC®T互补选择性。对于许多氨基酸，α, β, γ环状，尤其是含有硫的蛋氨酸、组氨酸和半胱氨酸的分辨度增高。对于一些中性分子，比如恶唑烷酮、乙内酰脲类和二氮嗪，分辨度也增强了，尤其在单溶剂甲醇、乙醇和乙腈中效果显著。一些酸性分子选择性也增强了
- 连接相：替考拉宁苷元
- pH适用范围：3.0 - 6.8
- 粒子直径：5, 10或16 μm
- 孔径：100 Å
應用
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This study emphasizes the effectiveness of the Astec® CHIROBIOTIC® TAG Chiral HPLC Column in the enantioseparation of complex cyclic amino acids. The methodology detailed provides profound insights into the chirality aspects of biochemical molecules, which is crucial for the synthesis of novel pharmaceutical agents and the study of biochemical pathways. This research supports analytical chemists in academia focused on developing chiral analytical methods and advancing chemical synthesis (Berkecz et al., 2009).
法律資訊
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Ilaria D'Acquarica et al.
Journal of chromatography. A, 1061(2), 167-173 (2005-01-12)
We describe a new tandem-columns chiral-achiral HPLC arrangement by using a chiral column (CHIROBIOTIC TAG) connected in series with an achiral column (Spherisorb S5 SCX), based on a strong cationic exchange mechanism; this approach is very useful for the analysis
Abdulrahman A Al-Majed
Journal of pharmaceutical and biomedical analysis, 50(1), 96-99 (2009-05-19)
A direct chiral high-performance liquid chromatography (HPLC) method was developed and validated for the resolution and quantification of antiepileptic drug enantiomers, R-(-)- and S-(+)-vigabatrin (gamma-vinyl-gamma-aminobutyric acid) in pharmaceutical products. The separation was optimized on a macrocyclic glycopeptide antibiotic chiral stationary
Markus Fuereder et al.
Journal of chromatography. A, 1236, 123-131 (2012-04-03)
Teicoplanin aglycone-based chromatography columns (Chirobiotic TAG) enable amino acid enantioseparation with aqueous mobile phases, which perfectly accommodates the distinct hydrophilicity of most amino acids. Therefore, this stationary phase constitutes a promising option in particular for preparative-scale separations that require high
Adsorption behavior of a teicoplanin aglycone bonded stationary phase under harsh overload conditions
Bechtold, Matthias, et al.
Journal of Chromatography A, 1154 (1-2), 2477-2286 (2007)
Matthias Bechtold et al.
Journal of chromatography. A, 1113(1-2), 167-176 (2006-02-28)
The suitability of a teicoplanin-aglycone based chiral stationary phase for the simulated moving bed (SMB) enantioseparation of amino acids under enzyme-compatible conditions was shown following a procedure that is based solely on model-based simulations and HPLC experiments. A set of
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