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品質等級
化驗
≥98% (HPLC)
形狀
powder
儲存條件
desiccated
protect from light
顏色
white
溶解度
H2O: >10 mg/mL
起源
Wyeth
SMILES 字串
Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2
InChI
1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H
InChI 密鑰
QYRYFNHXARDNFZ-UHFFFAOYSA-N
基因資訊
human ... SLC6A2(6530) , SLC6A4(6532)
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生化/生理作用
文拉法辛是抗抑郁药。文拉法辛在人中的抗抑郁作用机制与其在中枢神经系统中神经递质活性的增强有关。文拉法辛是神经元 5-羟色胺和去甲肾上腺素再摄取的有效抑制剂,是多巴胺再摄取的弱抑制剂。在体外,文拉法辛对毒蕈碱、组胺能或 α-1 肾上腺素能受体无明显活性。文拉法辛不具有 MAO 抑制剂活性。
特點和優勢
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
危險聲明
危險分類
Aquatic Chronic 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
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Organic micro-contaminants (OMCs) enter in freshwaters and interact with other contaminants such as carbon nanoparticles, becoming a problem of unknown consequences for river ecosystems. Carbon nanoparticles (as fullerenes C60) are good adsorbents of organic contaminants and their interaction can potentially
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Venlafaxine is a bicyclic antidepressant that may be associated with severe cardiotoxicity following large overdose. The purpose of this short case series is to present different patterns of venlafaxine-related cardiotoxicity and to discuss the potential mechanisms. Between January 2010 and
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(32), 4092-4098 (2013-10-02)
Hot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men. Eligible androgen-deprived men were randomly assigned to one of four daily regimens (2 × 2 factorial design) for 12
The American journal of psychiatry, 170(2), 197-206 (2012-12-12)
OBJECTIVE Deficits in positive affect and their neural bases have been associated with major depression. However, whether reductions in positive affect result solely from an overall reduction in nucleus accumbens activity and fronto-striatal connectivity or the additional inability to sustain
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Few epidemiologic studies have investigated the use of venlafaxine (Effexor XR capsules, Product Monograph, Wyeth, Montreal, Canada), an antidepressant used to treat major depression and anxiety disorders in adults, during pregnancy. Our objective was to determine whether use of venlafaxine
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