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品質等級
化驗
≥98% (HPLC)
形狀
solid
顏色
white
mp
86-87 °C (lit.)
溶解度
DMSO: 24 mL/mL
H2O: insoluble
SMILES 字串
CCCCC(=O)Oc1ccccc1C(O)=O
InChI
1S/C12H14O4/c1-2-3-8-11(13)16-10-7-5-4-6-9(10)12(14)15/h4-7H,2-3,8H2,1H3,(H,14,15)
InChI 密鑰
WJHZBTMHUNVIKC-UHFFFAOYSA-N
生化／生理作用
Selective, irreversible COX-1 inhibitor. The selectivity for COX-1 vs COX-2 shows the IC50 values for ovine COX-1 vs COX-2 of 0.8 μM vs. 15 mM respectively.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Eduardo Candelario-Jalil et al.
Journal of neuroinflammation, 4, 25-25 (2007-10-12)
Neuroinflammatory responses are triggered by diverse ethiologies and can provide either beneficial or harmful results. Microglial cells are the major cell type involved in neuroinflammation, releasing several mediators, which contribute to the neuronal demise in several diseases including cerebral ischemia
Cai Liang et al.
Biochemical pharmacology, 159, 11-24 (2018-11-11)
Augmented endothelium-dependent contractions (EDC) contributes to endothelial dysfunction and vascular disease progression. An early signal in EDC is cytosolic [Ca2+]i rise in endothelial cells, which stimulates the production of contractile prostanoids, leading to vascular contraction. In this study, the molecular
Ju-Fang Liu et al.
Molecular cancer, 9, 43-43 (2010-02-25)
Cyclooxygenase (COX)-2, the inducible isoform of prostaglandin (PG) synthase, has been implicated in tumor metastasis. Interaction of COX-2 with its specific EP receptors on the surface of cancer cells has been reported to induce cancer invasion. However, the effects of
Karina Cristina Giannotti et al.
Scientific reports, 7(1), 4098-4098 (2017-06-24)
Crotoxin B (CB) is a catalytically active group IIA sPLA
Takayuki Matsumoto et al.
Biological & pharmaceutical bulletin, 39(3), 384-393 (2016-03-05)
We investigated the relationship between noradrenaline (NAd)-induced contractions, endothelial function, and hypertension in femoral arteries isolated from spontaneously hypertensive rats (SHR). In the femoral arteries of SHR, vs. age-matched control Wistar Kyoto (WKY) rats, contractions induced by NAd were increased.
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