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About This Item
经验公式（希尔记法）:
C11H9ClF3NO2
CAS号:
分子量:
279.64
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to off-white
溶解度
DMSO: >10 mg/mL
儲存溫度
room temp
SMILES 字串
CC(=O)CC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
InChI
1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)
InChI 密鑰
GNYIJZMBLZXJEJ-UHFFFAOYSA-N
應用
Fasentin已被用作葡萄糖转运蛋白（GLUT1）抑制剂，用于评估其对各种三阴性乳腺癌 (TNBC) 细胞系脆弱性的影响，并研究其对氢化可的松（HC）诱发的细胞毒性药物的作用。
生化／生理作用
Fastentin是一种葡萄糖摄入的全新抑制剂，GluT1抑制剂。Fastentin是一种全新的葡萄糖摄入抑制剂，可敏化细胞对FAS诱导的细胞死亡。Fastentin会选择性敏化死亡配体，但不会降低FLIP的表达。它会改变与营养和葡萄糖剥夺相关的基因表达。Fastentin可与葡萄糖转运蛋白GLUT1细胞间通道中一个独特的位点发生互作。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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