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化驗
≥98% (HPLC)
形狀
solid
顏色
white to light yellow
mp
179-183 °C
儲存溫度
2-8°C
SMILES 字串
Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2-c3ccccc3
InChI
1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
InChI 密鑰
QWCJHSGMANYXCW-UHFFFAOYSA-N
基因資訊
human ... CYP2C18(1562) , CYP2C19(1557) , CYP2C9(1559)
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生化／生理作用
抗细菌。CYP2C9的特异性抑制剂。阻断由CYP2C9介导的亚油酸（氧化应激和AP-1活化增加）的促炎症和致动脉粥样硬化作用。CYP2C9的特异性抑制剂。阻断由CYP2C9介导的亚油酸（氧化应激和AP-1活化增加）的促炎症和致动脉粥样硬化作用。抑制缓激肽诱导的tPA释放。
包裝
Bottomless glass bottle. Contents are inside inserted fused cone.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Mahmood Khan et al.
Antioxidants & redox signaling, 11(4), 725-738 (2008-10-16)
The objective of this study was to establish the cardioprotective effect of sulfaphenazole (SPZ), a selective inhibitor of cytochrome P450 2C9 enzyme, in an in vivo rat model of acute myocardial infarction (MI). MI was induced by 30 min ligation
Chengqun Huang et al.
American journal of physiology. Heart and circulatory physiology, 298(2), H570-H579 (2009-12-17)
Previously, we showed that sulfaphenazole (SUL), an antimicrobial agent that is a potent inhibitor of cytochrome P4502C9, is protective against ischemia-reperfusion (I/R) injury (Ref. 15). The mechanism, however, underlying this cardioprotection, is largely unknown. With evidence that activation of autophagy
Vienna E Brunt et al.
The Journal of physiology, 590(15), 3523-3534 (2012-06-08)
While it is accepted that NO is responsible for ∼60% of the plateau in cutaneous thermal hyperaemia, a large portion of the response remains unknown. We sought to determine whether the remaining ∼40% could be attributed to EDHF-mediated activation of
Yasuhiro Ishihara et al.
European journal of pharmacology, 611(1-3), 64-71 (2009-04-10)
The effects of inhibitors of cytochrome P450 on myocardial regional ischemia-reperfusion injury were examined in rats. Ischemia-reperfusion injury was evoked by ligation of the left anterior descending coronary artery for 1 h, followed by reperfusion for 24 h. Injuries were
Agostino Virdis et al.
The Journal of clinical endocrinology and metabolism, 95(2), 920-927 (2009-12-22)
The aim of this study was to assess whether patients with primary hyperparathyroidism (PHPT) show reduced endothelial function and to determine the mechanisms involved. The impact of parathyroidectomy (PTx) on endothelial function was also assessed. Endothelial dysfunction is reported in
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