推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~90 kDa
物種活性
mouse, human
濃度
~1 mg/mL
技術
western blot: 2-4 μg/mL using whole extracts of mouse brain and human Hela cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... UVRAG(7405)
mouse ... Uvrag(78610)
一般說明
Ultraviolet irradiation resistance-associated gene (UVRAG) is an important autophagic tumor suppressor, encoded by the gene mapped to human chromosome 11q13.5. The encoded protein is characterized with four functional domains, such as proline-rich domain, a lipid-binding C2 domain, a beclin1-binding coiled-coil domain (CCD) and a C-terminal domain involved in centrosome integrity and DNA damage repair.
免疫原
synthetic peptide corresponding to amino acids 665-678 of human UVRAG, conjugated to KLH. The corresponding sequence is identical in mouse.
應用
Anti-UVRAG antibody has been used in:
- immunoblotting
- western blotting
- immunofluorescence
Anti-UVRAG antibody produced in rabbit has been used:
- in western blotting
- in immunofluorescence
生化／生理作用
Ultraviolet irradiation resistance-associated gene (UVRAG) is implicated in the regulation of intracellular membrane trafficking, including autophagy and chromosomal stability. The encoded protein regulates apoptosis by suppressing the BCL2-associated X protein (Bax) activity. Mutation in the gene has been observed in various types of human cancers, including microsatellite unstable colon carcinomas.
標靶描述
UVRAG activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a prot
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila
Lee G, et al.
Developmental Biology, 356(2), 588-597 (2011)
UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
Knaevelsrud H, et al.
Autophagy, 6(7), 863-870 (2010)
Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers
He S
Nature Communications (2015)
UV irradiation resistance-associated gene suppresses apoptosis by interfering with BAX activation.
Yin X
EMBO Reports, 12, 727-734 (2011)
Chonsaeng Kim et al.
Journal of virology, 88(1), 434-443 (2013-10-25)
Echovirus 7 enters polarized Caco-2 intestinal epithelial cells by a clathrin-mediated endocytic process and then moves through the endosomal system before releasing its genome into the cytoplasm. We examined the possible role in virus entry of core components of the
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