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Merck

U5377

Sigma-Aldrich

尿嘧啶1-β-D-阿拉伯呋喃糖苷

lymphoma antiproliferative

别名:

Arauridine, Spongouridin, 1-β-D-阿拉伯呋喃糖尿嘧啶

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About This Item

经验公式(希尔记法):
C9H12N2O6
CAS号:
分子量:
244.20
Beilstein:
28749
EC號碼:
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

生物源

synthetic (organic)

化驗

≥98% (HPLC)

形狀

powder

溶解度

water: 50 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

OC[C@H]1O[C@H]([C@@H](O)[C@@H]1O)N2C=CC(=O)NC2=O

InChI

1S/C9H12N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16)/t4-,6-,7+,8-/m1/s1

InChI 密鑰

DRTQHJPVMGBUCF-CCXZUQQUSA-N

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一般說明

阿糖尿苷(1-β-d-arabinofuranosyluracil, Ara-U)是阿糖胞苷 (1-β-d-arabinofuranosylcytosin, Ara-C) 的解毒产物或代谢产物。阿糖尿苷(Uracil 1-β-D-arabinofuranoside)是一种名为阿糖胞苷 (CYT) 的细胞生长抑制剂的人体代谢物。

應用

阿糖尿苷(Uracil 1-β-D-arabinofuranoside)可用作通过亲水相互作用色谱/串联质谱法分析医院废水细胞抑制剂和代谢物含量的标准化合物,检验分析实验的可行性和局限性。它还可用作化学分析标准品,研究细胞毒性抗肿瘤药物的生态毒性和遗传毒性,如阿糖胞苷 (CYT) 及其代谢物(如阿糖尿苷(uracil-1-β-d-arabinofuranoside, AraU))。

生化/生理作用

17 μM浓度的阿糖尿苷(1-β-D-Arabinofuranosyluracil, ara-U)能够抑制 L5178Y 小鼠淋巴瘤细胞增殖。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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其他客户在看

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Metabolism of 1-beta-D-arabinofuranosyluracil in mouse L5178Y cells.
W E Müller et al.
Cancer research, 39(3), 1102-1107 (1979-03-01)
Zibo Li et al.
Current radiopharmaceuticals, 4(1), 24-30 (2011-12-24)
[18F]FMAU is an established PET probe used to monitor cellular proliferation. For clinical applications, a fully automated cGMP-compliant radiosynthesis would be preferred. However, the current synthesis of [18F]FMAU requires HBr activation of the sugar prior to the coupling with silylated
Jia Hu et al.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 31(5), 693-695 (2011-11-01)
In this study, a novel technique for the preparation of (125)I-5-trimethylstannyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) urail (FIAU) was developed, (125)I-FIAU biodistribution profile was detected in Kunming mice and the possibility of using FTAU radio-labeling for reporter gene imaging was explored. 5-trimethylstannyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) urail (FTAU) was
Yoon-Ok Jang et al.
BMC gastroenterology, 12, 4-4 (2012-01-11)
Clevudine is a nucleoside analog reverse transcriptase inhibitor that exhibits potent antiviral activity against hepatitis B virus (HBV) without serious side effects. However, mitochondrial myopathy has been observed in patients with chronic HBV infection taking clevudine. Moreover, the development of
[New drugs of treatment of patients with chronic hepatitis B].
Fumitaka Suzuki
Nihon rinsho. Japanese journal of clinical medicine, 69 Suppl 4, 512-514 (2011-11-22)

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