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Merck
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文件

F0503

Sigma-Aldrich

5-氟-2′-脱氧尿嘧啶核苷

thymidylate synthase inhibitor

别名:

2′-脱氧-5-氟脲苷, FUDR, 氟脲苷

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About This Item

经验公式（希尔记法）:
C9H11FN2O5
CAS号:
50-91-9
分子量:
246.19
Beilstein:
90221
EC號碼:
200-072-5
MDL號碼:
MFCD00006530
分類程式碼代碼:
12352202
PubChem物質ID:
24894724
NACRES:
NA.77

生物源

synthetic (organic)

品質等級

200

化驗

≥99% (HPLC)

形狀

powder

mp

148 °C (lit.)

溶解度

water: 50 mg/mL, clear, colorless to faintly yellow

儲存溫度

room temp

SMILES 字串

OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(F)C(=O)NC2=O

InChI

1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

InChI 密鑰

ODKNJVUHOIMIIZ-RRKCRQDMSA-N

基因資訊

human ... TYMS(7298)
mouse ... Tyms(22171)

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一般說明

5-氟-2′-脱氧脲核苷，也称为氟脲苷，可在癌细胞中引起DNA介导的细胞毒性作用。氟脲苷可有效治疗肝癌 并且能够清除金黄色葡萄球菌（ Staphylococcus aureus）的毒性。氟脲苷与吉西他滨的二肽前药组合具有更强的细胞渗透性和抗增殖活性。氟脲苷能够有效治疗实体瘤和晚期癌症。

應用

5-氟-2′-脱氧脲核苷已被用作施旺（schwann）细胞增殖、胶质细胞增殖 和背根神经节培养物中非神经细胞的有丝分裂抑制剂。

生化／生理作用

一种抗肿瘤药物，是胸苷酸合成酶的有效抑制剂 通过低水平支原体感染，可使癌细胞培养物产生FUdR耐受性。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Elite Possik et al.
PLoS genetics, 10(4), e1004273-e1004273 (2014-04-26)
Dysregulation of AMPK signaling has been implicated in many human diseases, which emphasizes the importance of characterizing AMPK regulators. The tumor suppressor FLCN, responsible for the Birt-Hogg Dubé renal neoplasia syndrome (BHD), is an AMPK-binding partner but the genetic and
S G Louie et al.
British journal of cancer, 109(7), 1744-1749 (2013-09-12)
The aging process is accompanied by physiological changes including reduced glomerular filtration and hepatic function, as well as changes in gastric secretions. To investigate what effect would aging have on the disposition of capecitabine and its metabolites, the pharmacokinetics between
Diana Andrea Fernandes de Abreu et al.
PLoS genetics, 10(3), e1004225-e1004225 (2014-03-29)
Insulin-like peptides (ILPs) play highly conserved roles in development and physiology. Most animal genomes encode multiple ILPs. Here we identify mechanisms for how the forty Caenorhabditis elegans ILPs coordinate diverse processes, including development, reproduction, longevity and several specific stress responses.
Cheng Shi et al.
Science (New York, N.Y.), 343(6170), 536-540 (2013-12-21)
Interactions between the germ line and the soma help optimize reproductive success. We discovered a phenomenon linking reproductive status to longevity: In both hermaphroditic and gonochoristic Caenorhabditis, mating leads to female shrinking and death, compressing postreproductive life span. Male sperm
The Dipeptide Monoester Prodrugs of Floxuridine and Gemcitabine?Feasibility of Orally Administrable Nucleoside Analogs
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Pharmaceuticals (Basel, Switzerland), 7(2), 169-191 (2014)
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