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生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous glycerol solution
用途
sufficient for 10 blots
物種活性
mammals
技術
immunohistochemistry (frozen sections): 1:1,000
indirect immunofluorescence: 1:1,000
western blot: 1:1,000 using rat brain lysates of PC-12 cells stimulated by okadaic acid
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
一般說明
酪氨酸羟化酶 (TH) 由定位于人染色体 11p15 的基因编码。TH 是四种相同亚基组成的四聚体，特征是含有一个调节、催化和四聚体化结构域。该酶利用酪氨酸、四氢生物蝶呤 (BH4) 和 O2 作为辅底物，并利用 Fe2+ 作为辅因子。
免疫原
从嗜铬细胞瘤中纯化并经SDS变性的大鼠酪氨酸羟化酶。
生化／生理作用
酪氨酸羟化酶 (TH) 催化儿茶酚胺神经递质生物合成的第一个限速步骤，即 L-酪氨酸转化为 L-多巴的过程。L-苯丙氨酸对 TH 的抑制作用可能在苯丙酮尿症中发挥关键作用，并可阻止去甲肾上腺素合成。TH 活性可通过磷酸化来调节。TH 表达下调与各种神经精神疾病有关，例如精神分裂症和帕金森病 (PD)。
標靶描述
酪氨酸羟化酶（TH）可参与到苯丙氨酸向多巴胺的转化。它可催化儿茶酚胺生物合成途径的初始限速步骤。
外觀
含有10mM HEPES，pH 7.5、150mM NaCl、100 μg/mL BSA和50%甘油的100 μL溶液。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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