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品質等級
化驗
≥95% (HPLC)
應用
metabolomics
vitamins, nutraceuticals, and natural products
SMILES 字串
COc1ccc(cc1)C2=CC(=O)c3c(OC)c(OC)c(OC)c(OC)c3O2
InChI
1S/C20H20O7/c1-22-12-8-6-11(7-9-12)14-10-13(21)15-16(23-2)18(24-3)20(26-5)19(25-4)17(15)27-14/h6-10H,1-5H3
InChI 密鑰
ULSUXBXHSYSGDT-UHFFFAOYSA-N
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一般說明
桔皮素是一种多甲氧基黄酮，主要从柑橘类水果的果皮中提取，如 甜橙 和 中国桔子。
應用
桔皮素已被用作抗氧化剂和抗真菌剂，用于测试其对 稻瘟病原菌的铁死亡抑制、分生孢子发育和附着胞形成的影响。它还被用作辅助化疗剂，以研究其与5-氟尿嘧啶(5-Fu)联合使用对WiDr结肠癌细胞的细胞毒性作用。
生化／生理作用
在 体外 和 体内 研究中，桔皮素通过调节几种癌症类型中的不同途径来发挥其抗癌作用。它还具有抗氧化、抗炎和雌激素特性。
桔皮素是一种在柑橘类水果皮中发现的黄酮类化合物，它最有可能对真菌产生天然抗性。 桔皮素已被证明可以抵消肿瘤启动子诱导的细胞间通讯抑制，并可抑制几种癌症细胞的细胞增殖。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
其他客户在看
Jérôme Quintin et al.
Bioorganic & medicinal chemistry letters, 19(13), 3502-3506 (2009-05-22)
A series of 3'-aminoflavones 5,6,7,8-tetra- or 5,7-dioxygenated on the A-ring was synthesized from tangeretin or naringin, two natural Citrus flavonoids. These flavones were evaluated for antiproliferative activity, activation of apoptosis, and inhibition of tubulin assembly. The most antiproliferative flavones exhibit
El-Shaimaa A Arafa et al.
Cancer research, 69(23), 8910-8917 (2009-11-12)
Combination of innocuous dietary components with anticancer drugs is an emerging new strategy for cancer chemotherapy to increase antitumor responses. Tangeretin is a citrus flavonoid known to inhibit cancer cell proliferation. Here, we show an enhanced response of A2780/CP70 and
Lun-zhao Yi et al.
Analytica chimica acta, 649(1), 43-51 (2009-08-12)
Tangerine peels are herbal materials of two coupled traditional Chinese medicines, Pericarpium Citri Reticulatae (PCR) and Pericarpium Citri Reticulatae Viride (PCRV). In this paper, high-performance liquid chromatographic fingerprints of tangerine peels during growth were firstly measured for deliberately collected 34
Ai Eguchi et al.
BioFactors (Oxford, England), 31(2), 107-116 (2008-09-23)
Unregulated uptake of oxidized low-density lipoproteins (ox-LDL) via macrophage scavenger receptors (SRs) is a key event in atherosclerosis. We previously reported that nobiletin (NOB), a citrus polymethoxylated flavone, markedly reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced SRs and adhesion molecules mRNA expression and blockade
Ji Hye Yoon et al.
Journal of agricultural and food chemistry, 59(1), 222-228 (2010-12-04)
The present study examined the effects of tangeretin, a polymethoxylated flavonone present in citrus fruits, on ultraviolet B (UVB)-induced cyclooxygenase-2 (COX-2) expression in JB6 P+ mouse skin epidermal cells. Tangeretin suppressed UVB-induced COX-2 expression and transactivation of nuclear factor-κB and
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