推荐产品
产品名称
抗-β微管蛋白III （神经元）抗体，小鼠单克隆 小鼠抗, ~1.0 mg/mL, clone 2G10, purified from hybridoma cell culture
生物源
mouse
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
2G10, monoclonal
形狀
buffered aqueous solution
分子量
antigen ~50 kDa
物種活性
human, mouse, rat
包裝
antibody small pack of 25 μL
濃度
~1.0 mg/mL
技術
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 0.25-0.5 μg/mL using PC12 cell extract
同型
IgG2a
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TUBB3(10381)
mouse ... Tubb3(22152)
rat ... Tubb3(246118)
一般說明
微管蛋白 β 3 III类（TUBB3）也称 β-微管蛋白III，由定位于人染色体16q24.3的基因编码。TUBB3蛋白表达仅限于神经元。
應用
小鼠抗β-微管蛋白III（神经元）单克隆抗体还可用于以下研究：
- 免疫荧光。
- 免疫细胞化学。
生化／生理作用
微管蛋白 β 3 III类（TUBB3）在神经系统发育和轴突导向中起着至关重要的作用。编码蛋白的基因发生突变会导致眼动障碍、3型先天性眼外肌纤维化（CFEOM3）和各种神经综合征。蛋白表达的改变会影响微管动力学和微管-驱动蛋白相互作用。在肿瘤组织中，TUBB3的表达上调。TUBB3的表达下调可以作为皮肤恶性黑素瘤预后不良的重要标志物。TUBB3参与抑制肿瘤组织的侵袭性生长；因此，它是开发抗肿瘤药物的潜在靶标。
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
其他說明
免責聲明
除非我们的产品目录或产品随附的其他公司文档中另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人或动物。
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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