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生物源
rabbit
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 80-100 kDa
物種活性
human
加強驗證
recombinant expression
Learn more about Antibody Enhanced Validation
濃度
~1 mg/mL
技術
immunoprecipitation (IP): 10-20 μg using TGN46 from human HepG2 cell lysates.
indirect immunofluorescence: 5-10 μg/mL using human A549 cells
western blot (chemiluminescent): 0.25-0.5 μg/mL using extracts of human HEK-293T cells expressing recombinant human TGN46
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... TGOLN2(10618)
一般說明
TGN46（反式高尔基体网络蛋白，46 kDa）是大鼠TGN38的人类同源物，是反式高尔基体网络（TGN）的固有整合膜蛋白，其可在TGN和质膜之间进行组成性循环，并通过内体返回。TGN是蛋白质分泌途径、脂质和膜运输的的主要分选细胞器。TGN46是一种高度糖基化的蛋白质，可能参与调节往返TGN的膜运输。TGN46包含信号肽、内腔结构域、跨膜结构域和胞质结构域。跨膜区域和胞质尾巴分别包含保留和回收信号，可用于TGN的定位。TGN46在细胞中广泛表达。
抗TGN46可识别人反式高尔基体网络蛋白2（TGN46）。通过免疫印迹对TGN46条带的检测可被免疫肽特异性抑制。
免疫原
对应于人TGN46的氨基酸残基426-437的合成肽，N-末端添加有半胱氨酸，并与KLH偶联。与大鼠中的相应序列相同，与人的相应序列相差2个氨基酸。
應用
兔多克隆抗TGN46抗体可用于标记反式高尔基体网络蛋白2，并可通过免疫细胞化学和免疫组化（IHC）技术（例如免疫印迹、免疫沉淀和免疫荧光）进行检测和定量。它可作为探针，对反式高尔基网络蛋白2[作为反式高尔基网络（TGN）的膜转运调节成分]的存在和作用进行确定。抗TGN46可用作TGN标记。
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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