- HID-1 is a novel player in the regulation of neuropeptide sorting.
HID-1 is a novel player in the regulation of neuropeptide sorting.
The Biochemical journal (2011-01-22)
Yong Yu, Lifen Wang, Yaming Jiu, Yi Zhan, Lin Liu, Zhiping Xia, Eli Song, Pingyong Xu, Tao Xu
PMID21250940
摘要
Peptide hormones and neuropeptides are packaged and stored in a specialized intracellular organelle called the dense core vesicle. It remains elusive how peptide cargoes are correctly sorted. In the present study, we show that a highly conserved Golgi-localized protein named HID-1 acts to prevent mis-sorting of peptide cargoes to lysosomes for degradation via a PtdIns3P-dependent trafficking pathway. Epistasis analysis suggests that rab-2 is epistatic to hid-1.