T5705

Terrein

from Aspergillus terreus, ≥98% (HPLC)

• 别名: (+)Terrein, Terrain
• 经验公式（希尔记法）: C₈H₁₀O₃
• CAS号: 582-46-7
• 分子量: 154.16
• 分類程式碼代碼: 12352200
• NACRES: NA.77

属性

• 生物源: Aspergillus terreus
• 品質等級: 200
• 化驗: ≥98% (HPLC)
• 儲存條件: protect from light
• 溶解度: H₂O: soluble 1-1.10 mg/mL, clear, colorless; DMSO: soluble
• 儲存溫度: −20°C
• InChI: 1S/C8H10O3/c1-2-3-5-4-6(9)8(11)7(5)10/h2-4,7-8,10-11H,1H3/b3-2+
• InChI 密鑰: MHOOPNKRBMHHEC-NSCUHMNNSA-N

说明

生化／生理作用

Terrein is a bioactive fungal metabolite that has plant growth inhibition and antibacterial activities. Terrein reduces melanin levels in a dose-dependent manner as well as tyrosinase protein production. In mammals, there are three melanocyte-specific enzymes: tyrosinase, tyrosinase-related protein-1 (TRP-1), and TRP-2 that are involved in tyrosine conversion into melanin (melanogenesis). Terrein inhibits melanin synthesis by reducing tyrosinase production via extracellular signal-regulated protein kinase (ERK) activation. ERK activation is followed by microphthalmia-associated transcription factor (MITF) down regulation, which is required for tyrosinase expression.

準備報告

Terrein is soluble in water at 1-1.10 mg/ml and yields a clear, colorless solution. It is also soluble in DMSO. Hence, the product may be reconstituted in water or DMSO.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable