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product name
Transforming Growth Factor-β2 human, TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture
生物源
human
品質等級
重組細胞
expressed in NSO cells
化驗
≥97% (electrophoresis)
形狀
powder
效力
0.04 ng/mL ED50
品質
endotoxin tested
分子量
25 kDa
包裝
pkg of 10 μg
pkg of 2 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
≤1 EU/μg
適合性
suitable for
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... TGFB2(7042) , TGFBR2(7048)
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一般說明
The transforming growth factor-β2 (TGFB2) gene is mapped to human chromosome 1q41. The encoded protein is localized to extracellular matrix. TGF-β2 is a member of the TGF-β superfamily. TGF-β exists in three isoforms (TGF-β1, TGF-β2 and TGF-β3) and are known to share similar structure and function.
應用
Transforming Growth Factor-β2 human has been used in chondrogenic, adipogenic and osteogenic differentiation of mesenchymal stem cells. It has also been used to induce extracellular matrix accumulation in primary human trabecular meshwork cells and further to study the action of tetramethylpyrazine on the same.
生化／生理作用
TGF-β2 is known to stimulate cell growth, differentiation, migration and survival. TGF-β2 acts as a key regulator for immune homeostasis by controlling lymphocyte proliferation, embryogenesis, hematopoiesis and apoptosis. TGF-β is also associated with inflammation and wound healing and is considered as a strong growth inhibitor for keratinocyte cells. TGF-β is associated with the process of tumor development, progression and metastasis. TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis. The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.
Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.
外觀
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.1 mg bovine serum albumin
分析報告
The biological activity is measured by its ability to inhibit the IL-4-dependent proliferation of mouse HT-2 cells.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
TGF-β1 and TGF-β2 abundance in liver diseases of mice and men
Dropmann A, et al.
Oncotarget, 7(15), 19499?19518-19499?19518 (2016)
Transforming growth factor β (TGF-β) and inflammation in cancer.
Bierie B and Moses HL
Cytokine & Growth Factor Reviews, 21.1, 49-59 (2010)
Evaluation of zinc finger E-box binding homeobox 1 and transforming growth factor-β2 expression in bladder cancer tissue in comparison with healthy adjacent tissue
Mahdavinezhad A, et al.
Investigative and Clinical Urology, 58(2), 140?145-140?145 (2017)
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm
Lindsay ME, et al.
Nature Genetics, 44(8), 922?927-922?927 (201)
A signaling pathway involving TGF-β2 and snail in hair follicle morphogenesis.
Jamora C, et al.
PLoS Biology, 3.1 (2004)
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