T1775

L-甲状腺素

powder, BioReagent, suitable for cell culture

• 别名: 3,3′,5,5″-四碘代-L-甲状腺原氨酸, 3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸, T₄
• 线性分子式: HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
• CAS号: 51-48-9
• 分子量: 776.87
• Beilstein: 2228515
• EC號碼: 200-101-1
• MDL號碼: MFCD00002595
• 分類程式碼代碼: 12352209
• eCl@ss: 32190102
• PubChem物質ID: 24899990
• NACRES: NA.77

属性

• 生物源: synthetic
• 產品線: BioReagent
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 效力: 5-50 ng/mL
• 技術: cell culture | mammalian: suitable
• mp: 223 °C (dec.) (lit.)
• 溶解度: 4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, yellow
• 運輸包裝: ambient
• 儲存溫度: room temp
• SMILES 字串: N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
• InChI 密鑰: XUIIKFGFIJCVMT-LBPRGKRZSA-N
• 基因資訊: human ... THRA(7067) , THRB(7068) , TTR(7276) ; mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

说明

一般說明

Thyroxine (T₄) is a tetraiodo derivative of the p-hydroxyphenyl ether of tyrosine, which functions as growth factors or cell growth inhibitors. T₄ is used to treat hypothyroidism and thyroid carcinoma. It regulates energy metabolism.

應用

L-Thyroxine has been used to investigate its role in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant). It has also been used to evaluate its effects on pro-inflammatory tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), angiogenic vascular endothelial growth factor (VEGF), leukocyte adhesion, intercellular adhesion molecule 1 (ICAM-1) and E-selectin in human umbilical vein endothelial cells (HUVECs).

生化／生理作用

L甲状腺素 (T₄) 和三碘代-L-甲状腺原氨酸 (T₃) 为含碘激素，由甲状腺卵泡细胞中的甲状腺球蛋白制备。这些激素对代谢率的刺激以及对生长发展的调节似乎归因于它们对 DNA 转录的作用，进而影响蛋白质的合成。

準備報告

For long term storage, keep stock solutions at -20° in working aliquots and avoid repeated freeze/thaw cycles. Solutions stored at 2-8 °C are stable for up to 30 days.

重構

To prepare 20 μg/ml stock solution, dissolve in 50 ml sterile culture medium per mg thyroxine.

安全信息

• 象形圖: GHS08
• 訊號詞: Danger
• 危險聲明: H372
• 防範說明: P260 - P264 - P270 - P314 - P501
• 危險分類: STOT RE 1
• 標靶器官: Thyroid,Cardio-vascular system,Kidney
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)