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T1505

Sigma-Aldrich

四异丙基焦磷酸亚胺

butyrylcholinesterase inhibitor

别名:

四（单阳离子基）焦磷酸四胺, 异-OMPA

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About This Item

经验公式（希尔记法）:
C12H32N4O3P2
CAS号:
513-00-8
分子量:
342.36
EC號碼:
208-149-5
MDL號碼:
MFCD00048272
分類程式碼代碼:
12352202
PubChem物質ID:
24278724
NACRES:
NA.77

生物源

synthetic

mp

149-151 °C

儲存溫度

−20°C

SMILES 字串

CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C

InChI

1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)

InChI 密鑰

IOIMDJXKIMCMIG-UHFFFAOYSA-N

基因資訊

human ... ACHE(43) , BCHE(590)

應用

四异丙基焦磷酰胺已被用于：
  • 作为丁酰胆碱酯酶抑制剂，用于测定猫和虎血浆中丁酰胆碱酯酶 (BChE) 的比例
  • 在乙酰胆碱酯酶测定中抑制野生型 BChE
  • 选择性阻断 AChE 的酶活性

生化／生理作用

丁酰胆碱酯酶的选择性抑制剂

警告

警告：极其危险！在使用本产品之前，请注意风险并熟悉安全程序。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300 + H310 + H330

危險分類

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

儲存類別代碼

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Ilaria Corsi et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 145(3), 413-419 (2007-02-28)
To address the potential role of cholinesterase enzymes in the invasive capacity of species, the present study investigated ChE activity in the invasive freshwater bivalve Anodonta woodiana (Lea, 1834) comparing it with that of the indigenous species, Anodonta sp. (Linnaeus
Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase
Wang YW, et al.
Toxicology and Applied Pharmacology, 196(3), 356-366 (2004)
Ming-Kuem Lin et al.
Molecules (Basel, Switzerland), 23(12) (2018-11-24)
The seeds of Cuscuta chinensis Lam. and C. campestris Yuncker have been commonly used as Chinese medical material for preventing aging. Our previous studies have found that C. chinensis and C. campestris possess anti-inflammatory activities in rodents. However, their other
Liyi Geng et al.
PloS one, 8(6), e67446-e67446 (2013-07-11)
Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a
A A Kousba et al.
Toxicology, 188(2-3), 219-232 (2003-05-28)
The primary mechanism of action for organophosphorus (OP) insecticides such as chlorpyrifos (CPF) involves the inhibition of acetylcholinesterase (AChE) by their active oxon metabolites resulting in a wide range of neurotoxic effects. These oxons also inhibit other cholinesterases (ChE) such
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