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生物源
human
重組細胞
expressed in E. coli
化驗
≥95% (SDS-PAGE)
形狀
liquid
分子量
40.8 kDa (1081-1197 aa + NT GST Tag)
包裝
pkg of 20 and 100 μg
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... CREB1(1385)
一般說明
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The cAMP response element-binding protein (CREB) binding protein (CREBBP) bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53. This product contains the bromodomain region of CREBBP.
外觀
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol.
訊號詞
Warning
危險分類
Aquatic Chronic 3 - Eye Irrit. 2 - Skin Sens. 1
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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