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Merck
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Key Documents

SRP6560

Sigma-Aldrich

Wnt-2 human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

别名:

INT1L1, IRP, Int-1-like protein 1, Int-1-related protein

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About This Item

分類程式碼代碼:
12352202
NACRES:
NA.32

生物源

human

重組細胞

expressed in E. coli

化驗

≥90% (SDS-PAGE)

形狀

lyophilized

分子量

39.9 kDa

包裝

pkg of 1 mg
pkg of 10 μg
pkg of 50 μg

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... WNT2(7472)

生化/生理作用

Wnt gene family members, including Wnt-1 through Wnt-10, play a key role in regulating cellular growth and differentiation. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Wnt family member-2 (Wnt-2) has a role in activating β-catenin. It has been shown to have a role in cardiogenesis. The protein is overexpressed in tumors and cancers.

外觀

Lyophilized without additives.

重構

Reconstitute in sterile ddH2O to a concentration ≥ 100 μg/mL.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Wnt signal transduction pathways
Yuko Komiya
Organogenesis, 4(2), 68-75 (2008)
Overexpression of Wnt-2 in colorectal cancers.
Park JK
Neoplasma, 56(2), 119-123 (2009)
Wnt2 is a direct downstream target of GATA6 during early cardiogenesis
Alexander A
Mechanisms of Development, 123, 297-311 (2006)
Wnt2 complements Wnt/?-catenin signaling in colorectal cancer
Youn-Sang Jung
Oncotarget, 6(35), 37257-37268 (2015)
Wnt2 as a new therapeutic target in malignant pleural mesothelioma
Julien Mazieres
International Journal of Cancer. Journal International Du Cancer (2005)

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