推荐产品
生物源
human
重組細胞
expressed in HEK 293 cells
籤條
6-His tagged (C-terminus)
化驗
≥95% (SDS-PAGE)
形狀
lyophilized
分子量
calculated mol wt 45 kDa
observed mol wt 60-90 kDa (DTT-reduced. Cys 32 is the predicted N-terminal.)
包裝
pkg of 10 and 50 μg
雜質
<1 EU/μg endotoxin (LAL test)
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... NTRK2(4915)
一般說明
The NTRK2 (neurotrophic tyrosine kinase receptor type 2) gene is mapped to human chromosome 9q21.33 and is predominantly expressed in subcutaneous fat and also expressed in visceral fat. Insulin receptor subfamily. NTRK2 / TrkB contains two Ig-like C2-type (immunoglobulin-like) domains, two LRR (leucine-rich) repeats, one LRRCT domain, one LRRNT domain, one protein kinase domain. NTRK2 / Trk-B is expressed in the central and peripheral nervous system. The catalytic activity of NTRK2 is “ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate”.
生化／生理作用
Neurotrophic tyrosine kinase receptor type 2 (NTRK2) is an oncogenic receptor tyrosine kinase. Abnormal expression of the NTRK2 gene is associated with several cancers including colorectal, breast and papillary thyroid cancer, lung adenocarcinoma and oral squamous cell carcinoma. NTRK2 also known as tropomyosin-related kinase B (TRKB) and is activated by binding of a number of neurotrophins including brain-derived neurotrophic factor(BDNF), neurotrophin 3 (NT-3) and neurotrophic ⅘ (NT-4/5). NTRK2 is involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity.
外觀
Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.
重構
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
The receptor tyrosine kinase ROR1?an oncofetal antigen for targeted cancer therapy.
Hojjat-Farsangi M, et al.
Seminars in Cancer Biology, 29, 21-31 (2014)
A new aspect of the TrkB signaling pathway in neural plasticity.
Ohira K and Hayashi M
Current Neuropharmacology, 7(4), 276-285 (2009)
Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF ?/? mouse model of amyotrophic lateral sclerosis.
Brockington A, et al.
BMC Genomics, 11(1), 203-203 (2010)
Transplantation of adipose tissue and stem cells: role in metabolism and disease.
Tran T T and Kahn C R
Nature reviews. Endocrinology, 6(4), 195-195 (2010)
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