推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
物種活性
rat, human, mouse
濃度
~1.2 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 2.5-5.0 μg/mL using biotin/ExtrAvidin®-Peroxidase staining of heat-retrieved rat brain sections
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5.0-10.0 μg/mL using biotin/ExtrAvidin®-Peroxidase staining of heat-retrieved human and mouse brain sections
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... NGB(58157)
一般說明
Neuroglobin is an oxygen-binding heme protein predominantly expressed in the nervous system in man and other vertebrates. Neuroglobin belongs to the globin superfamily. It displays the typical globin fold, but it shares little amino acid sequence similarity with vertebrate hemoglobins and myoglobins. Neuroglobin is highly conserved among vertebrates and is evolutionary related to the invertebrate nerve globins. In mouse and rat, neuroglobin is preferentially expressed in neuronal cells of the central and peripheral nervous systems, but also in some endocrine tissues. Neuroglobin is highly expressed in neurons of mammalian retina.
免疫原
synthetic peptide corresponding to amino acids 55-70 of human neuroglobin, conjugated to KLH.
應用
Anti-Neuroglobin antibody produced in rabbit has been used in
- immunofluorescence double staining
- immunostaining
- immunohistochemistry
生化／生理作用
Neuroglobin may play an essential role in oxygen homeostasis of neuronal cells. Neuroglobin is thought to protect neurons from hypoxic-ischemic injury as suggested by its increased expression under hypoxic conditions in- vitro as well as in focal cerebral ischemia in vivo. Neuronal survival after hypoxia decreased when neuroglobin expression is inhibited by antisense oligonucleotide and enhanced by neuroglobin overexpression. Its distribution correlates with the subcellular localization of mitochondria and with oxygen demands, possibly linking neuroglobin to cellular respiration.
標靶描述
Neuroglobin is an oxygen-binding heme proteinpredominantly expressed in the nervous system.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
法律資訊
ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Susi Zara et al.
Gerontology, 59(3), 250-260 (2013-02-23)
Alzheimer's disease (AD) is a frequent form of senile dementia. Neuroglobin (Ngb) has a neuroprotective role and decreases Aβ peptide levels. Ngb, promoting Akt phosphorylation, activates cell survival involving cyclic-nucleotide response element-binding protein (CREB). A new molecule (IBU-LA) was synthetized
Divergent Distribution in Vascular and Avascular Mammalian Retinae Links Neuroglobin to Cellular Respiration
Bentmann A, et al.
The Journal of Biological Chemistry, 280(21), 20660-20665 (2005)
Zindy Raida et al.
Experimental & translational stroke medicine, 4(1), 15-15 (2012-08-21)
Neuroglobin is considered to be a novel important pharmacological target in combating stroke and neurodegenerative disorders, although the mechanism by which this protection is accomplished remains an enigma. We hypothesized that if neuroglobin is directly involved in neuroprotection, then permanent
Neuroglobin involvement in visual pathways through the optic nerve
Lechauve C, et al.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1834(9), 1772-1778 (2013)
A vertebrate globin expressed in the brain
Burmester T, et al.
Nature, 407(6803), 520-523 (2000)
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