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生物源
human
重組細胞
expressed in E. coli
化驗
≥98% (SDS-PAGE)
形狀
lyophilized
效力
2-5 ng/mL ED50 (it′s ability to stimulate the proliferation of human SH-SY5Y cells)
分子量
~24 kDa
包裝
pkg of 20 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
endotoxin, tested
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... ARTN(9048)
一般說明
Human Artemin, a neurotrophic factor, belongs to the GDNF family. Artemin is a survival factor for sensory and sympathetic neurons in culture. Recombinant human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits. The gene encoding this protein is localized on human chromosome 1p34.1.
生化／生理作用
Artemin (ART/ARTN) is a survival factor for sensory and sympathetic neurons in culture. It has a role in promoting survival of neurons. ART is also involved in the differentiation and development of the central and peripheral nervous systems. The protein promotes axonal projection and migration in sympathetic neurons. Artemin restores neural damage and diminishes neuropathic pain. It has been associated with various carcinomas.
外觀
Lyophilized from 10 mM Sodium Citrate pH 4.5 plus 150 mM NaCl.
準備報告
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
重構
Reconstitute in water to a concentration of 0.1-0.5 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
Recontitute in PBS containing at least 0.1% BSA to a concentration of 0.1-1.0 mg/mL. This stock solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling.
Banerjee A et al.
PLoS ONE, 7(11) (2012)
MouseFinder: Candidate disease genes from mouse phenotype data
Chao-Kung Chen, et al.
Human Mutation (2012)
ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1-VEGF-A signalling.
Baneerje A, et al.
PLoS ONE, 7(11) null
Neurotrophic factor artemin promotes invasiveness and neurotrophic function of pancreatic adenocarcinoma in vivo and in vitro
Li Gao, Haiji Bo, et al
Pancreas, 44.1, 134-134 (2015)
Neurotrophic factor artemin promotes invasiveness and neurotrophic function of pancreatic adenocarcinoma in vivo and in vitro
Li Gao,et al.
Pancreas, 134 (2015)
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