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生物源
human
重組細胞
expressed in E. coli
化驗
≥98% (HPLC)
≥98% (SDS-PAGE)
形狀
lyophilized
分子量
12.4 kDa
包裝
pkg of 10 μg
技術
cell culture | mammalian: suitable
雜質
<0.1 EU/μg endotoxin, tested
顏色
white to off-white
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... IL16(3603)
一般說明
IL-16 (interleukin 16), or LCF (lymphocyte chemoattractant factor), was first functionally and biochemically characterized in 1982. IL-16 is produced as a precursor protein (pro-IL16), composed of 631 residues which undergoes cleavage by caspase-3 to produce and secrete a C-terminal biologically active peptide of 121 amino acids. This gene is localized to human chromosome 15q26.3.
生化／生理作用
IL-16 (interleukin 16) is a pleiotropic proinflammatory cytokine that stimulates chemotactic and immunomodulatory responses of CD4+ (cluster of differentiation) lymphocytes, monocytes, and eosinophils, via signaling through CD4. It prevents HIV (human immunodeficiency virus) replication, and promotes the expression of IL-2R by human T-cells. Study in Chinese population show that polymorphisms in this gene are linked with susceptibility to knee osteoarthritis (OA). IL-16 plays a key role in the release of tumor-related inflammatory cytokines, and the rs4778889 variant in this gene is linked with increased risk of RCC (renal cell cancer) in Chinese population.
Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4kDa protein consisting of 121 amino acid residues.
Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4kDa protein consisting of 121 amino acid residues.
序列
SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S
外觀
Lyophilized from 5 mM Sodium Citrate, pH 5.5 + 0.5 mM DTT.
重構
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a stabilizer (example 5% Trehalose) and store in working aliquots at -20°C to -80°C.
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
Assignment of human interleukin 16 (IL16) to chromosome 15q26.3 by radiation hybrid mapping.
Kim HS
Cytogenetics and Cell Genetics, 84(1-2), 93-93 (1999)
Conservation of structure and function between human and murine IL-16.
Keane J et al
Journal of Immunology, 160(12), 5945-5954 (1998)
IL-16 rs4778889 polymorphism contribution to the development of renal cell cancer in a Chinese population.
Yang SX et al
Genetics and molecular research : GMR, 15(2) (2016)
W W Cruikshank et al.
Journal of immunology (Baltimore, Md. : 1950), 157(12), 5240-5248 (1996-12-15)
We have recently described the cDNA and predicted protein structure of a natural soluble CD4 ligand, IL-16. IL-16 is chemotactic for CD4+ T cells and induces functional IL-2 receptors in CD4+ T cells. The binding of IL-16 to CD4 results
Center, D.M., et al.
Cytokine Reference, 226-240 (2001)
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