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Merck
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主要文件

SRP3030

Sigma-Aldrich

ENA-78 (8-78) human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

别名:

CXCL5, Epithelial Neutrophil Activating Peptide-78, LIX (murine)

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

human

重組細胞

expressed in E. coli

化驗

≥98% (HPLC)
≥98% (SDS-PAGE)

形狀

lyophilized

效力

10.0-100.0 ng/mL

分子量

7.8 kDa

包裝

pkg of 20 μg

技術

cell culture | mammalian: suitable

雜質

<0.1 EU/μg endotoxin, tested

顏色

white to off-white

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... CXCL5(6374)

一般說明

ENA-78 (epithelial cell-derived neutrophil activating peptide-78) is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. ENA-78 is a chemoattractant for neutrophils. The murine homolog of ENA-78 is called LIX. Three N-terminal truncated variants of human ENA-78; ENA 5-78, ENA 8-78, ENA 9-78, contain 74, 71, and 70 amino acid residues, respectively, possess increased biological activity. ENA-78 contains the four conserved cysteine residues present in CXC chemokines, and also contains the ‘ELR′ motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues. The ENA-78 gene is mapped to human chromosome 4q13.3.

生化/生理作用

ENA-78 (epithelial cell-derived neutrophil activating peptide-78) gene expression is associated with sepsis, atherosclerosis, COPD (chronic obstructive pulmonary disease), psoriasis and gastrointestinal inflammation. ENA-78 is angiogenic factor and is associated with cancer progression. Upregulation of ENA-78 gene is observed in non‐small‐cell lung cancer, head, neck, gastric, pancreatic, colorectal, prostate and lung cancer squamous cell carcinoma.
ENA-78 is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. Recombinant human ENA-78 is a 7.8 kDa protein consisting of 71 amino acid residues.

序列

LRELRCVCLQ TTQGVHPKMI SNLQVFAIGP QCSKVEVVAS LKNGKEICLD PEAPFLKKVI QKILDGGNKE N

外觀

Lyophilized with no additives.

重構

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析证书(COA)

Lot/Batch Number

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访问文档库

CXCL5 (chemokine (CXC motif) ligand 5).
Bulysheva A A and Yeudall W A
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2013)
Interleukin?17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment.
Ruddy M J, et al.
Journal of Leukocyte Biology, 76(1), 135-144 (2004)
CXC chemokines in angiogenesis of cancer.
Strieter R M, et al.
Seminars in Cancer Biology, 14(3), 195-200 (2004)
Chemokine receptors in inflammation: an overview.
D'Ambrosio D, et al.
Journal of Immunological Methods, 273(1-2), 3-13 (2003)
CXC chemokines in angiogenesis.
Belperio J A, et al.
Journal of Leukocyte Biology, 68(1), 1-8 (2000)

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