SRP0570

5′-NUCLEOTIDASE/CD73, His-Tag

recombinant, expressed in HEK 293 cells

• 别名: 5′- nucleotidase, Ecto-5′-nucleotidase
• 分類程式碼代碼: 12352202
• NACRES: NA.26

属性

• 重組細胞: expressed in HEK 293 cells
• 形狀: frozen liquid
• 分子量: 58.6 kDa
• UniProt登錄號: P21589
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... NT5E(4907)

说明

一般說明

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

應用

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

生化／生理作用

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

外觀

Aqueous solution

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319
• 防範說明: P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable