SML3770

BMS-466442

≥98% (HPLC)

• 别名: (S)-Methyl 3-(1-benzyl-1H-imidazol-4-yl)-2-(6-benzyloxy-5-methoxy-1H-indole-2-carboxamido)propanoate, BMS 466442, BMS466442, N-[[5-Methoxy-6-(phenylmethoxy)-1H-indol-2-yl]carbonyl]-1-(phenylmethyl)-L-histidine methyl ester
• 经验公式（希尔记法）: C₃₁H₃₀N₄O₅
• CAS号: 1598424-76-0
• 分子量: 538.59
• MDL號碼: MFCD35060520
• 分類程式碼代碼: 12352200

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: powder
• 顏色: white to beige
• 溶解度: DMSO: 2 mg/mL, clear
• 儲存溫度: -10 to -25°C
• SMILES 字串: COC([C@H](CC1=CN(C=N1)CC2=CC=CC=C2)NC(C(NC3=C4)=CC3=CC(OC)=C4OCC5=CC=CC=C5)=O)=O

说明

生化／生理作用

Potent and selective alanine serine cysteine transporter-1 (ASC-1; SLC7A10) inhibitor that effectively blocks ASC-1-mediated cellular D-Ser uptake.



BMS-466442 is a selective alanine serine cysteine transporter-1 (ASC-1) inhibitor (D-Ser uptake IC50 = 36.8 nM and 19.7 nM using HEK human ASC-1 transfectants or primary rat embryonic cortical cultures, respectively) with good selectivity over >40 other targets, including LAT-2 or ASCT-2 (IC50 >10 μM).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable