SML3754
SRT2104
≥98% (HPLC)
别名:
4-Methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(pyridin-3-yl)thiazole-5-carboxamide, 4-Methyl-N-(2-{3-[(morpholin-4-yl)methyl]imidazo[2,1-b][1,3]thiazol-6-yl}phenyl)-2-(pyridin-3-yl)-1,3-thiazole-5-carboxamide, GSK 2245840B, GSK-2245840B, GSK2245840B, SRT 2104, SRT-2104
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About This Item
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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear (Warmed)
儲存溫度
-10 to -25°C
SMILES 字串
[s]1c(nc(c1C(=O)Nc3c(cccc3)c4nc5[s]cc([n]5c4)CN6CCOCC6)C)c2cnccc2
InChI 密鑰
LAMQVIQMVKWXOC-UHFFFAOYSA-N
生化／生理作用
Orally active sirtuin 1 (Sirt1) activator in vitro and in vivo.
SRT2104 is an orally active, potent and highly selective activator of the NAD+-dependent deacetylase sirtuin Sirt1 (EC1.5 = 450 nM) with in vivo efficacy in various animal models, including age-related bone/muscle loss (100 mg/kg/d via chow to mice), HD (0.5% in chow to mice), TNF-induced optic nerve degeneration (2-200 pmol via intravitreal injection to rats).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
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